Relationships between QUS and HR-pQCT, DXA, and bone turnover markers
Relationships between QUS and HR-pQCT, DXA, and bone turnover markers
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QUS 与 HR-pQCT、DXA 和骨转换标志物之间的关系
DOI：
10.1007/s00774-022-01346-2
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发表时间：
2022
影响因子：
3.3
通讯作者：
Osaki Makoto
中科院分区：
文献类型：
--
作者：
Niimi Ryuji;Chiba Ko;Okazaki Narihiro;Yonekura Akihiko;Tomita Masato;Osaki Makoto
本文分析了定量超声（QUS）与高分辨率外周定量计算机断层扫描（HR-pQCT）、双能x线吸收仪（DXA）、骨相关生化指标的关系。材料与方法研究对象为480人。用跟骨QUS测量声速（SOS）。采用HR-pQCT评估桡骨远端和胫骨骨小梁和皮质骨的体积骨密度（vBMD）和显微结构。采用DXA法测定腰椎和股骨近端骨密度（aBMD）。生化检测TRACP-5b、P1NP、25 （OH）维生素D、戊苷。对所有受试者、性别和年龄组的每个参数进行相关性分析。结果squs与Tb呈中度相关。vBMD和Tb。桡骨和胫骨的BV/TV。与Ct无相关性。vBMD或皮质孔隙度（Ct.Po）。尽管所有受试者的胫骨皮质厚度（Ct.Th）均有相关性，但在年龄≥60岁的女性中未见相关性。QUS与股骨近端aBMD有中度相关性。虽然在所有受试者中腰椎aBMD与中度相关，但在年龄≥60岁的受试者中未见相关性。QUS与生化指标间无显著相关性。结论QUS与结核有中度相关性。桡骨和胫骨的vBMD和微结构以及股骨近端aBMD。另一方面，与Ct几乎没有相关性。vBMD或Ct。Po和骨相关生化标志物。只有在中年人中，与Ct呈正相关。在胫骨和腰椎的aBMD。
IntroductionRelationship of quantitative ultrasound (QUS) with high-resolution peripheral quantitative computed tomography (HR-pQCT), dual-energy X-ray absorptiometry (DXA), and bone-related biochemical markers was analyzed.Materials and methodsThe subjects were 480 individuals. Speed of sound (SOS) was measured by calcaneal QUS. Volumetric bone mineral density (vBMD) and microarchitecture of trabecular and cortical bone in the distal radius and tibia were assessed by HR-pQCT. Areal bone mineral density (aBMD) in the lumbar spine and proximal femur were measured by DXA. TRACP-5b, P1NP, 25 (OH) vitamin D, and pentosidine were evaluated by biochemical tests. The correlation of each parameter was analyzed for all subjects and by sex and age group.ResultsQUS was moderately correlated with Tb.vBMD and Tb.BV/TV in the radius and tibia. No correlation was seen with Ct.vBMD or cortical porosity (Ct.Po). Although a correlation was seen with cortical thickness (Ct.Th) in the tibia in all subjects, no correlation was seen in women aged ≥ 60 years.QUS showed moderate correlations with aBMD in the proximal femur. Although moderate correlation was seen with aBMD in the lumbar spine in all subjects, no correlation was seen in subjects aged ≥ 60 years. No significant correlations were seen between QUS and biochemical markers.ConclusionsModerate correlations were seen between QUS and Tb.vBMD and microarchitecture in the radius and tibia and aBMD of the proximal femur. On the other hand, practically no correlations were seen with Ct.vBMD or Ct.Po and the bone-related biochemical markers. Only in middle age, moderate correlations were seen with Ct.Th in the tibia and with aBMD of the lumbar spine.
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