Regulating Early Biological Events in Human Amniotic Epithelial Stem Cells Using Natural Bioactive Compounds: Extendable Multidirectional Research Avenues.

Regulating Early Biological Events in Human Amniotic Epithelial Stem Cells Using Natural Bioactive Compounds: Extendable Multidirectional Research Avenues.
复制标题

DOI:
10.3389/fcell.2022.865810
复制
发表时间:
2022
影响因子:
5.5
通讯作者:
--
中科院分区:
生物学2区
文献类型:
--
作者:

文献摘要

参考文献

被引文献

相似文献

从围产期组织中分离的干细胞具有巨大的生物医学和临床应用潜力。另一方面,新出现的数据表明,具有生物活性的天然化合物调节干细胞中的许多细胞和生化功能,促进细胞迁移、增殖和附着,从而维持干细胞增殖或诱导受控分化。在我们之前的研究中,我们首次报道了多种天然化合物可以通过调节早期生物学和分子事件以谱系特异性的方式诱导hAESCs的靶向分化,并通过调节分子信号传导增强hAESCs的治疗潜力。从这个角度来看,我们将讨论在hAESCs中使用天然活性化合物的优势及其在生物学研究和临床应用中的潜在意义。
Stem cells isolated from perinatal tissue sources possess tremendous potential for biomedical and clinical applications. On the other hand, emerging data have demonstrated that bioactive natural compounds regulate numerous cellular and biochemical functions in stem cells and promote cell migration, proliferation, and attachment, resulting in maintaining stem cell proliferation or inducing controlled differentiation. In our previous studies, we have reported for the first time that various natural compounds could induce targeted differentiation of hAESCs in a lineage-specific manner by modulating early biological and molecular events and enhance the therapeutic potential of hAESCs through modulating molecular signaling. In this perspective, we will discuss the advantages of using naturally occurring active compounds in hAESCs and their potential implications for biological research and clinical applications.
DOI: 10.3390/biomedicines10010048
发表时间: 2021-12-27
期刊: Biomedicines
影响因子: 4.7
作者:
Ferdousi F;Furuya K;Sasaki K;Zheng YW;Oda T;Isoda H
通讯作者: Isoda H
DOI: 10.1186/s12964-020-00697-5
发表时间: 2021-02-24
期刊: Cell communication and signaling : CCS
影响因子: --
作者:
Bejaoui M;Ferdousi F;Zheng YW;Oda T;Isoda H
通讯作者: Isoda H
DOI: 10.3389/fcell.2016.00135
发表时间: 2016
影响因子: 5.5
作者:
Di Germanio C;Bernier M;de Cabo R;Barboni B
通讯作者: Barboni B
DOI: 10.3389/fcell.2020.00175
发表时间: 2020-03-25
影响因子: 5.5
作者:
Bejaoui, Meriem;Villareal, Myra O.;Isoda, Hiroko
通讯作者: Isoda, Hiroko
人羊膜上皮细胞对肝纤维化大鼠模型中促纤维化肝细胞的影响。
DOI: 10.1111/jcmm.13396
发表时间: 2018-03
影响因子: 5.3
作者:
Cargnoni A;Farigu S;Cotti Piccinelli E;Bonassi Signoroni P;Romele P;Vanosi G;Toschi I;Cesari V;Barros Sant'Anna L;Magatti M;Silini AR;Parolini O
通讯作者: Parolini O