Bioinspired mineralized collagen scaffolds for bone tissue engineering.
Bioinspired mineralized collagen scaffolds for bone tissue engineering.
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用于骨组织工程的仿生矿化胶原支架
DOI：
10.1016/j.bioactmat.2020.11.004
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发表时间：
2021-05
影响因子：
18.9
通讯作者：
Niu X
中科院分区：
文献类型：
--
作者：
Li Z;Du T;Ruan C;Niu X
大节段骨缺损的成功再生仍然是临床骨科面临的重大挑战，因此制造合适的替代材料来刺激骨再生具有重要意义。由于其优异的生物相容性、足够的机械强度以及与天然骨相似的结构和成分，矿化胶原支架（MCS）已越来越多地通过组织工程方法用作骨替代品。在此，我们全面总结了 MCS 作为加速骨修复的组织工程支架的最新技术，包括其制造方法、成骨调节的关键因素、当前的机遇和未来的挑战。首先，本文提出了目前MCS的制造方法，主要包括直接矿物复合、原位矿化和3D打印技术，以改善其仿生物理结构。同时，物理（力学和形态）、生物（细胞和生长因子）和化学（组成和交联）三个方面的线索被描述为调节MCS成骨特征的关键因素。最后，还讨论了与 MCS 作为骨组织工程支架相关的机遇和挑战，指出了构建下一代 MCS 的未来方向，该下一代 MCS 应具有令人满意的模拟结构和适当的骨再生生物学特性。详细推荐了MCS建设的最新进展。人们提出了多种调节方法来增强 MCS 的成骨作用。讨论了 MCS 作为骨组织工程支架的机会。
Successful regeneration of large segmental bone defects remains a major challenge in clinical orthopedics, thus it is of important significance to fabricate a suitable alternative material to stimulate bone regeneration. Due to their excellent biocompatibility, sufficient mechanical strength, and similar structure and composition of natural bone, the mineralized collagen scaffolds (MCSs) have been increasingly used as bone substitutes via tissue engineering approaches. Herein, we thoroughly summarize the state of the art of MCSs as tissue-engineered scaffolds for acceleration of bone repair, including their fabrication methods, critical factors for osteogenesis regulation, current opportunities and challenges in the future. First, the current fabrication methods for MCSs, mainly including direct mineral composite, in-situ mineralization and 3D printing techniques, have been proposed to improve their biomimetic physical structures in this review. Meanwhile, three aspects of physical (mechanics and morphology), biological (cells and growth factors) and chemical (composition and cross-linking) cues are described as the critical factors for regulating the osteogenic feature of MCSs. Finally, the opportunities and challenges associated with MCSs as bone tissue-engineered scaffolds are also discussed to point out the future directions for building the next generation of MCSs that should be endowed with satisfactorily mimetic structures and appropriately biological characters for bone regeneration. The recent progresses for building MCSs are recommended in detail. Various regulation approaches are presented for enhancing the osteogenesis of MCSs. The opportunities for MCSs as bone tissue-engineered scaffolds are discussed.
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影响因子：
3.7
作者：
Aisha, M. D.;Nor-Ashikin, M. N. K.;Froemming, G. R. A.
通讯作者：
Froemming, G. R. A.
影响因子：
5.2
作者：
Bilousova, Ganna;Jun, Du Hyun;King, Karen B.;De Langhe, Stijn;Chick, Wallace S.;Torchia, Enrique C.;Chow, Kelsey S.;Klemm, Dwight J.;Roop, Dennis R.;Majka, Susan M.
通讯作者：
Majka, Susan M.
影响因子：
3.1
作者：
Chatzipanagis, Konstantinos;Iafisco, Michele;Manuel Delgado-Lopez, Jose
通讯作者：
Manuel Delgado-Lopez, Jose
DOI：
10.1093/jmicro/dfr010
发表时间：
2011-06-01
期刊：
JOURNAL OF ELECTRON MICROSCOPY
影响因子：
--
作者：
Andronescu, Ecaterina;Voicu, Georgeta;Ficai, Anton
通讯作者：
Ficai, Anton
重组人血小板衍生的生长因子BB的临床前毒理学研究或与β-三磷酸β-磷酸β-型胶原蛋白结合使用。
影响因子：
8.2
作者：
Young CS;Bradica G;Hart CE;Karunanidhi A;Street RM;Schutte L;Hollinger JO
通讯作者：
Hollinger JO