Mother's physical activity during pregnancy and newborn's brain cortical development.
Mother's physical activity during pregnancy and newborn's brain cortical development.
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母亲在怀孕期间的体育锻炼和新生儿的大脑皮质发育。
DOI：
10.3389/fnhum.2022.943341
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发表时间：
2022
影响因子：
2.9
通讯作者：
中科院分区：
文献类型：
--
作者：
众所周知，体力活动可以改善心理健康，并且被认为是安全和理想的无并发症的怀孕。在这项新的研究中，我们的目的是评估母亲在怀孕期间的身体活动和新生儿大脑皮层发育之间是否存在关联。44个母亲/新生儿二对被纳入这项纵向研究。招募了健康的孕妇，并在怀孕4-10周、2012周、2018周、2024周、2030周和2036周的6个时间点中的每一个时间点使用佩戴3-7天的加速度计记录她们在整个怀孕期间的身体活动。从每个时间点的加速度计中提取平均每日总步数和每日总活动计数以及久坐/轻度/中度/剧烈活动模式下的每日分钟数。在出生后102周，他们的新生儿在没有镇静的情况下接受了脑部MRI检查，并通过iBEAT2.0软件利用先进的深度学习方法对3D T1加权脑结构图像进行了后处理。从分割的脑图像重建皮质表面图，并将其分成每个脑半球的34个区域，计算每个区域的平均皮质厚度，用于与体力活动测量的部分相关性分析，并进行适当的多重比较校正和潜在的混杂因素控制。怀孕4-10周时，母亲的每日总活动计数呈正相关（FDR校正P ≤ 0.05），新生儿左侧尾侧额中回皮质厚度（rho = 0.48，P = 0.04），右内侧眶额回（rho = 0.48，P = 0.04），右侧颞横回（rho = 0.48，P = 0.04）;母亲每日中度活动时间与新生儿右侧颞横回皮质厚度呈正相关（rho = 0.53，P = 0.03）。孕10 ~ 24周时，母亲每日总活动计数与新生儿左侧扣带回峡部皮质厚度（rho = 0.56，P = 0.02）和右侧扣带回峡部皮质厚度（rho = 0.50，P = 0.05）呈正相关（FDR校正P ≤ 0.05）。我们确定了健康孕妇在第一和第二个三个月期间的身体活动与新生儿大脑皮层发育之间的显着关系。母亲体力活动水平越高，新生儿大脑皮质厚度越大，可能表明皮质发育越好。
Physical activity is known to improve mental health, and is regarded as safe and desirable for uncomplicated pregnancy. In this novel study, we aim to evaluate whether there are associations between maternal physical activity during pregnancy and neonatal brain cortical development. Forty-four mother/newborn dyads were included in this longitudinal study. Healthy pregnant women were recruited and their physical activity throughout pregnancy were documented using accelerometers worn for 3–7 days for each of the 6 time points at 4–10, ∼12, ∼18, ∼24, ∼30, and ∼36 weeks of pregnancy. Average daily total steps and daily total activity count as well as daily minutes spent in sedentary/light/moderate/vigorous activity modes were extracted from the accelerometers for each time point. At ∼2 weeks of postnatal age, their newborns underwent an MRI examination of the brain without sedation, and 3D T1-weighted brain structural images were post-processed by the iBEAT2.0 software utilizing advanced deep learning approaches. Cortical surface maps were reconstructed from the segmented brain images and parcellated to 34 regions in each brain hemisphere, and mean cortical thickness for each region was computed for partial correlation analyses with physical activity measures, with appropriate multiple comparison corrections and potential confounders controlled. At 4–10 weeks of pregnancy, mother’s daily total activity count positively correlated (FDR corrected P ≤ 0.05) with newborn’s cortical thickness in the left caudal middle frontal gyrus (rho = 0.48, P = 0.04), right medial orbital frontal gyrus (rho = 0.48, P = 0.04), and right transverse temporal gyrus (rho = 0.48, P = 0.04); mother’s daily time in moderate activity mode positively correlated with newborn’s cortical thickness in the right transverse temporal gyrus (rho = 0.53, P = 0.03). At ∼24 weeks of pregnancy, mother’s daily total activity count positively correlated (FDR corrected P ≤ 0.05) with newborn’s cortical thickness in the left (rho = 0.56, P = 0.02) and right isthmus cingulate gyrus (rho = 0.50, P = 0.05). We identified significant relationships between physical activity in healthy pregnant women during the 1st and 2nd trimester and brain cortical development in newborns. Higher maternal physical activity level is associated with greater neonatal brain cortical thickness, presumably indicating better cortical development.
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影响因子：
3.8
作者：
Mandolesi L;Polverino A;Montuori S;Foti F;Ferraioli G;Sorrentino P;Sorrentino G
通讯作者：
Sorrentino G
影响因子：
5.7
作者：
Li G;Nie J;Wang L;Shi F;Gilmore JH;Lin W;Shen D
通讯作者：
Shen D
影响因子：
3.7
作者：
Domingues MR;Matijasevich A;Barros AJ;Santos IS;Horta BL;Hallal PC
通讯作者：
Hallal PC
影响因子：
5.1
作者：
Clapp, JF
通讯作者：
Clapp, JF
DOI：
10.1017/s2040174419000333
发表时间：
2020-04-01
影响因子：
1.7
作者：
Fragoso, Jessica;Carvalho Jurema Santos, Gabriela;Leandro, Carol Gois
通讯作者：
Leandro, Carol Gois