Aerobic capacity modulates adaptive thermogenesis: Contribution of non-resting energy expenditure.
Aerobic capacity modulates adaptive thermogenesis: Contribution of non-resting energy expenditure.
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DOI：
10.1016/j.physbeh.2020.113048
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发表时间：
2020-10-15
影响因子：
2.9
通讯作者：
Novak CM
中科院分区：
文献类型：
--
作者：
Mukherjee SD;Koch LG;Britton SL;Novak CM
能量储备的减少需要负能量平衡，当热量消耗超过能量摄入时，这可以诱导适应性生热-能量消耗(EE)的减少超出了体重损失的范围。适应性产热因个体而异。本研究使用肥胖倾向和体力活动不同的大鼠模型，研究了在适应性产热中，每日总EE的组成对个体间差异的影响。在50%卡路里限制的21天之前和21天后，对具有瘦削和肥胖倾向表型的雄性和雌性大鼠进行了每日总EE和体力活动的检测。卡路里限制显著降低EE，降幅超过体重和瘦体重的预测，显示出适应性产热作用。在性别上，Hcr和Lcr在静息EE上没有显著差异。然而，包括活动EE在内的非静息EE中卡路里限制诱导的抑制在HCR组显著大于LCR组；这种表型差异在雄性和雌性大鼠中都是显著的。卡路里限制也显著抑制了HCR的体力活动水平，而不是LCR。当对雄性大鼠的最大摄氧量进行评估时，限制卡路里显著降低了O2消耗，而对跑步性能(跑步时间、距离)没有显著影响，表明能量效率提高。体重减轻百分比在不同组之间没有显著差异。总之，这些结果表明，卡路里限制诱导的适应性产热的个体差异可能是有氧能力的变化所致。此外，活动EE，而不是休息或基础代谢，可能解释或预测个体适应性产热的变化。
Decreases in energy stores requires negative energy balance where caloric expenditure exceeds energy intake, which can induce adaptive thermogenesis—the reduction of energy expenditure (EE) beyond that accounted for by the weight lost. Adaptive thermogenesis varies between individuals. The component of total daily EE responsible for the interindividual variation in adaptive thermogenesis was investigated in this study, using a rat model that differs in obesity propensity and physical activity. Total daily EE and physical activity were examined before and after 21 days of 50% calorie restriction in male and female rats with lean and obesity-prone phenotypes—rats selectively bred for high and low intrinsic aerobic capacity (HCR and LCR, respectively). Calorie restriction significantly decreased EE more than was predicted by loss of weight and lean mass, demonstrating adaptive thermogenesis. Within sex, HCR and LCR did not significantly differ in resting EE. However, the calorie restriction-induced suppression in non-resting EE, which includes activity EE, was significantly greater in HCR than in LCR; this phenotypic difference was significant for both male and female rats. Calorie restriction also significantly suppressed physical activity levels more in HCR than LCR. When VO2max was assessed in male rats, calorie restriction significantly decreased O2 consumption without significantly affecting running performance (running time, distance), indicating increased energy efficiency. Percent weight loss did not significantly differ between groups. Altogether, these results suggest that individual differences in calorie restriction-induced adaptive thermogenesis may be accounted for by variation in aerobic capacity. Moreover, it is likely that activity EE, not resting or basal metabolism, may explain or predict the variation in individuals’ adaptive thermogenesis.
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影响因子：
8.3
作者：
Ladenvall, Per;Persson, Carina U.;Hansson, Per-Olof
通讯作者：
Hansson, Per-Olof
DOI：
10.1038/npp.2010.144
发表时间：
2011-01
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
通讯作者：
--
影响因子：
2.8
作者：
Fredriksen, PM;Veldtman, G;Webb, G
通讯作者：
Webb, G
影响因子：
120.7
作者：
Blair, SN;Kampert, JB;Gibbons, LW
通讯作者：
Gibbons, LW
影响因子：
8.2
作者：
Beery AK;Zucker I
通讯作者：
Zucker I