Maternal gut microbiota in the postpartum Period: A Systematic review.
Maternal gut microbiota in the postpartum Period: A Systematic review.
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DOI：
10.1016/j.ejogrb.2023.03.042
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发表时间：
2023-06
影响因子：
2.6
通讯作者：
Louis-Jacques, Adetola F.
中科院分区：
文献类型：
--
作者：
Weerasuriya, Wasana;Saunders, Julia E.;Markel, Lilla;Xu, Ke;Ho, Thao T. B.;Lemas, Dominick J.;Groer, Maureen W.;Louis-Jacques, Adetola F.
研究已经证明了肠道微生物群在怀孕期间的重要性，并且有关于产后母体肠道微生物群的新兴文献。本文的主要目的是综合有关产后肠道微生物组组成和主要足月婴儿的健康母亲粪便样本中测量的多样性的文献。次要目的是（1）确定影响产后母体肠道微生物群的生物和环境因素，以及（2）评估与所有母亲产后肠道微生物群变化相关的健康状况和临床中间措施。于2020年11月9日在PubMed、Embase、CINHAL、Scopus、科克伦图书馆、BioArchives和OpenGrey.eu上进行了电子检索，并于2021年7月25日进行了更新，没有发表时间限制。对产后（分娩后长达一年）母体肠道微生物群的初步研究是合格的。产后肠道微生物群与妊娠或非妊娠肠道微生物群的比较是令人感兴趣的，因此，除了产后研究之外，还包括了这些研究。如果研究仅在动物、婴儿、妊娠或其他身体部位的微生物组（例如，阴道的）。完成了微生物组成和多样性的数据提取和合成。评估研究的偏倚风险。在重复数据删除后，共筛选了2512篇文章，其中27篇纳入本综述。在纳入的27项研究中，有22项涉及主要目的。厚壁菌门是产后早期（<6周）和晚期（6周至1年）的优势门。产后早期以拟杆菌属为主。从产后早期到晚期的α和β多样性的纵向评估结果各不相同。27项研究中有19项评估了影响产后肠道微生物谱变化的生物和环境因素。分娩时间、益生菌补充、三氯生暴露和某些饮食影响产后肠道微生物群。关于8项研究中评估的健康状况和中期临床指标;炎症性肠病、产后抑郁症、早发性先兆子痫、妊娠期糖尿病、妊娠期体重过度增加和人体测量指标（如体重指数和腰臀比）与肠道微生物群变化相关。关于产妇产后肠道微生物群及其如何影响产妇健康的数据有限。我们需要了解产后母体肠道微生物组，确定它与非妊娠和妊娠状态的区别，并确定生物和环境影响因素。未来对肠道微生物组在产后对分娩父母的重要性的研究可能会对如何改善产妇的短期和长期健康产生新的认识。
Studies have demonstrated the importance of the gut microbiota during pregnancy, and there is emerging literature on the postpartum maternal gut microbiota. The primary objective of this paper was to synthesize the literature on the postpartum gut microbiome composition and diversity measured in stool samples from healthy mothers of predominantly term infants. The secondary objectives were (1) to identify biological and environmental factors that influence postpartum maternal gut microbiota and (2) to assess health conditions and clinical intermediate measures associated with postpartum gut microbiota changes in all mothers. Electronic searches were conducted November 9, 2020 and updated July 25, 2021 without publication time limits on PubMed, Embase, CINHAL, Scopus, Cochrane Library, BioArchives, and OpenGrey.eu. Primary research on maternal gut microbiota in the postpartum (up to one year after childbirth) were eligible. Postpartum gut microbiota comparisons to pregnancy or non-pregnancy gut microbiota were of interest, therefore, studies examining these in addition to the postpartum were included. Studies were excluded if they were only conducted in animals, infants, pregnancy, or microbiome of other body locations (e.g., vaginal). Data extraction of microbial composition and diversity were completed and synthesized narratively. Studies were assessed for risk of bias. A total of 2512 articles were screened after deduplication and 27 were included in this review. Of the 27 included studies, 22 addressed the primary objective. Firmicutes was the predominant phylum in the early (<6 weeks) and late postpartum (6 weeks to 1 year). In early postpartum, Bacteroides was the predominant genus. Findings from longitudinal assessments of alpha and beta diversity from the early to the late postpartum varied. Nineteen of the 27 studies assessed biological and environmental factors influencing the postpartum gut microbial profile changes. Timing of delivery, probiotic supplementation, triclosan exposure, and certain diets influenced the postpartum gut microbiota. Regarding health conditions and intermediate clinical measures assessed in 8 studies; inflammatory bowel disease, postpartum depression, early-onset preeclampsia, gestational diabetes, excessive gestational weight gain, and anthropometric measures such as body mass index and waist-to-hip ratio were related to gut microbiota changes. There is limited data on the maternal postpartum gut microbiota and how it influences maternal health. We need to understand the postpartum maternal gut microbiome, establish how it differs from non-pregnancy and pregnancy states, and determine biological and environmental influencers. Future research of the gut microbiome’s significance for the birthing parent in the postpartum could lead to a new understanding of how to improve maternal short and long-term health.
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影响因子：
5.9
作者：
Butts CA;Hedderley DI;Herath TD;Paturi G;Glyn-Jones S;Wiens F;Stahl B;Gopal P
通讯作者：
Gopal P
影响因子：
4.8
作者：
Halkjaer, Sofie Ingdam;de Knegt, Victoria Elizabeth;Petersen, Andreas Munk
通讯作者：
Petersen, Andreas Munk
DOI：
10.1097/mpg.0000000000000781
发表时间：
2015-08-01
影响因子：
2.9
作者：
Dotterud, Christian K.;Avershina, Ekaterina;Oien, Torbjorn
通讯作者：
Oien, Torbjorn
影响因子：
4.2
作者：
Carrothers, Janae M.;York, Mara A.;McGuire, Michelle K.
通讯作者：
McGuire, Michelle K.
影响因子：
5.9
作者：
Cortes-Martin, Adrian;Romo-Vaquero, Maria;Victoria Selma, Maria
通讯作者：
Victoria Selma, Maria