An overview about oxidation in clinical practice of skin aging.
An overview about oxidation in clinical practice of skin aging.
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DOI：
10.1590/abd1806-4841.20175481
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发表时间：
2017-05
影响因子：
1.7
通讯作者：
Leonardi GR
中科院分区：
文献类型：
--
作者：
Silva SAME;Michniak-Kohn B;Leonardi GR
自由基是不稳定的化学物质，高度反应性，由不同组织的细胞实体形成。如果没有内源性和外源性抗氧化系统的适当有效作用，这些物质的产生增加，会产生氧化应激的状况，潜在地提供从功能障碍延伸的皮肤疾病（皮肤癌、皮炎、慢性和急性炎症过程）甚至美学特征，随着结构蛋白质的破坏和细胞变化，随着污渍的出现，表情的痕迹和线条以及内在和外在皮肤老化过程所固有的其他迹象。抗氧化剂是临床实践中常用的化学物质，用于局部应用，并可能有助于对抗导致许多皮肤损伤的自由基物质。本文总结了皮肤局部应用抗氧化剂所带来益处的主要证据，考虑了体外和离体试验以及体内试验的抗氧化剂活性指示性能的幅度。人们认识到，应该探索广泛的产品性能测试，以真正确定抗氧化产品的抗衰老效果的有效性。
Free radicals are unstable chemical species, highly reactive, being formed by cellular entities of different tissues. Increased production of these species without proper effective action of endogenous and exogenous antioxidant systems, generates a condition of oxidative stress, potentially provider of skin disorders that extend from functional impairments (skin cancer, dermatitis, chronic and acute inflammatory processes) even aesthetic character, with the destruction of structural proteins and cellular changes with the appearance of stains, marks and lines of expressions and other signs inherent to the intrinsic and extrinsic skin aging process. The antioxidants are chemical substances commonly used in clinical practice for topical application and may contribute in the fight against the radical species responsible for many skin damage. This paper summarized the main evidence of the benefits brought by the topical application of antioxidants in the skin, considering the amplitude of the indicative performance of antioxidant activity by in vitro and ex-vivo tests as well as in vivo tests. It is recognized that a breadth of product performance tests should be explored to truly identify the effectiveness of antioxidant products for an anti-aging effect.
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影响因子：
7.4
作者：
Circu, Magdalena L.;Aw, Tak Yee
通讯作者：
Aw, Tak Yee
DOI：
10.1016/j.jpba.2004.10.030
发表时间：
2005-02-23
影响因子：
3.4
作者：
Di Mambro, VM;Fonseca, MJV
通讯作者：
Fonseca, MJV
影响因子：
8.8
作者：
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通讯作者：
Bayir, H
影响因子：
2.3
作者：
Buonocore, Daniela;Lazzeretti, Angelo;Marzatico, Fulvio
通讯作者：
Marzatico, Fulvio
影响因子：
5.8
作者：
Casagrande, Rubia;Georgetti, Sandra R.;Fonseca, Maria J. V.
通讯作者：
Fonseca, Maria J. V.