Cis-encoded non-coding antisense RNAs in streptococci and other low GC Gram (+) bacterial pathogens.
Cis-encoded non-coding antisense RNAs in streptococci and other low GC Gram (+) bacterial pathogens.
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DOI:
10.3389/fgene.2015.00110
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发表时间:
2015
影响因子:
3.7
通讯作者:
Kim JH
中科院分区:
文献类型:
--
作者:
Cho KH;Kim JH
Due to recent advances of bioinformatics and high throughput sequencing technology, discovery of regulatory non-coding RNAs in bacteria has been increased to a great extent. Based on this bandwagon, many studies searching for trans-acting small non-coding RNAs in streptococci have been performed intensively, especially in the important human pathogen, group A and B streptococci. However, studies for cis-encoded non-coding antisense RNAs in streptococci have been scarce. A recent study shows antisense RNAs are involved in virulence gene regulation in group B streptococcus, S. agalactiae. This suggests antisense RNAs could have important roles in the pathogenesis of streptococcal pathogens. In this review, we describe recent discoveries of chromosomal cis-encoded antisense RNAs in streptococcal pathogens and other low GC Gram (+) bacteria to provide a guide for future studies.
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