Cis-encoded non-coding antisense RNAs in streptococci and other low GC Gram (+) bacterial pathogens.

Cis-encoded non-coding antisense RNAs in streptococci and other low GC Gram (+) bacterial pathogens.
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DOI:
10.3389/fgene.2015.00110
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发表时间:
2015
影响因子:
3.7
通讯作者:
Kim JH
Kim JH
中科院分区:
生物学3区
文献类型:
--
作者:
Cho KH;Kim JH

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由于生物信息学和高通量测序技术的最新进展,细菌中调节性非编码RNA的发现已大大增加。基于这一趋势,许多在链球菌中寻找反式作用小非编码RNA的研究已经深入开展,特别是在重要的人类病原体A组和B组链球菌中。然而,对于链球菌中顺式编码的非编码反义RNA的研究却很少。最近的一项研究表明,反义 RNA 参与 B 族链球菌、无乳链球菌的毒力基因调控。这表明反义RNA可能在链球菌病原体的发病机制中发挥重要作用。在这篇综述中,我们描述了链球菌病原体和其他低 GC 革兰氏 (+) 细菌中染色体顺式编码反义 RNA 的最新发现,为未来的研究提供指导。
Due to recent advances of bioinformatics and high throughput sequencing technology, discovery of regulatory non-coding RNAs in bacteria has been increased to a great extent. Based on this bandwagon, many studies searching for trans-acting small non-coding RNAs in streptococci have been performed intensively, especially in the important human pathogen, group A and B streptococci. However, studies for cis-encoded non-coding antisense RNAs in streptococci have been scarce. A recent study shows antisense RNAs are involved in virulence gene regulation in group B streptococcus, S. agalactiae. This suggests antisense RNAs could have important roles in the pathogenesis of streptococcal pathogens. In this review, we describe recent discoveries of chromosomal cis-encoded antisense RNAs in streptococcal pathogens and other low GC Gram (+) bacteria to provide a guide for future studies.
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