The Effect of Body Adiposity and Alcohol Consumption on Serum Uric Acid: A Quantile Regression Analysis Based on the China National Health Survey.
The Effect of Body Adiposity and Alcohol Consumption on Serum Uric Acid: A Quantile Regression Analysis Based on the China National Health Survey.
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DOI：
10.3389/fnut.2021.724497
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发表时间：
2021
影响因子：
5
通讯作者：
Shan G
中科院分区：
文献类型：
--
作者：
He H;Pan L;Ren X;Wang D;Du J;Cui Z;Zhao J;Wang H;Wang X;Liu F;Pa L;Peng X;Wang Y;Yu C;Shan G
据报道，肥胖和饮酒与较高水平的血清尿酸（SUA）相关，但它们对SUA百分位数分布的影响是否存在差异仍不明确。在本研究中，我们旨在探究饮酒量、体脂百分比（%BF）与体重指数（BMI）相结合，对中国成年人SUA分布的影响。研究使用了来自中国国家健康调查（CNHS）的数据，该数据涵盖了中国10个省份的成年人（n = 31746，年龄20 - 80岁，男性占40%）。将%BF和BMI整合为八个扩展的身体成分组，以了解身体脂肪过多在人群层面如何影响SUA的分布。通过面对面问卷调查收集自我报告的饮酒信息。采用分位数回归（QR）对数据进行分析。我们发现，肥胖和饮酒与SUA相关，尤其是在两性的较高百分位数水平。在肥胖男性中，第75和第95百分位数的QR系数分别为74.0（63.1 - 84.9）μmol/L和80.9（52.5 - 109.3）μmol/L。男性中体脂百分比最高四分位数组在第95百分位数时的SUA水平比最低四分位数组高92.6（79.3 - 105.9）μmol/L（p < 0.001）。与体脂百分比最低的正常体重或体重不足组（NWBF1）相比，肥胖且体脂百分比最高组（OBBF4）对SUA的正向影响最强，尤其是在SUA较高百分位数时。在BMI定义的正常体重或体重不足参与者中，体脂百分比四分位数越高，对所有SUA百分位数的影响越大。在男性中，与SUA第5百分位数时的14.5（95%置信区间：8.4 - 20.6）相比，当前饮酒对SUA第95百分位数的影响最强（QR系数：31.8，95%置信区间：22.6 - 41.0）。高风险饮酒对SUA的影响更大，尤其是在SUA较高百分位数时。SUA较高百分位数处更强的相关性表明，在人群层面降低身体脂肪和饮酒量，可能会使SUA分布的上尾向较低值移动，从而降低高尿酸血症的发病率。
Adiposity and alcohol consumption are reported to be associated with a higher level of serum uric acid (SUA), but whether their effect differs on SUA percentile distribution is still unclear. In this study, we aimed to investigate how alcohol intake and body fat percentage (%BF) integrated with body mass index (BMI) influence the distribution of SUA in Chinese adults. Data from the China National Health Survey (CNHS) which included adults from 10 provinces of China were used (n = 31,746, aged 20–80 years, 40% male). %BF and BMI were integrated into eight expanded body composition groups to understand how excess body adiposity affects the distribution of SUA in the populational level. Self-report alcohol intake information was collected by face-to-face questionnaire interview. Quantile regression (QR) was used to analyze the data. We found that adiposity and alcohol consumption were associated with SUA, especially at the upper percentile in both sexes. In obese men, the QR coefficients at the 75th and 95th percentiles were 74.0 (63.1–84.9) and 80.9 (52.5–109.3) μmol/L, respectively. The highest quartile of %BF in men had a 92.6 (79.3–105.9) μmol/L higher SUA levels at its 95th percentile than the 5th quartile (p < 0.001). Compared with normal or underweight with the lowest %BF group (NWBF1), the obesity-highest %BF group (OBBF4) had the strongest positive effect on SUA, especially at the higher percentile of SUA. In BMI-defined normal or underweight participants, a higher quartile of %BF had greater effect size in all SUA percentiles. In men, current alcohol drinking had the strongest effect at the 95th percentile of SUA (QR coefficient: 31.8, with 95% CI: 22.6–41.0) comparing with 14.5, 95% CI of 8.4 to 20.6 in the 5th SUA percentile. High risk of alcohol consumption had a greater effect on SUA, especially in the higher SUA percentile. The observation of stronger association at the higher percentile of SUA suggests that decreasing body adiposity and alcohol intake at the populational level may shift the upper tails of the SUA distributions to lower values, thereby reducing the incidence of hyperuricemia.
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影响因子：
120.7
作者：
Ekelund, Ulf;Luan, Jian'an;Sherar, Lauren B.;Esliger, Dale W.;Griew, Pippa;Cooper, Ashley
通讯作者：
Cooper, Ashley
影响因子：
2.2
作者：
Dong, Xiaokang;Zhang, Honglei;Wang, Chongjian
通讯作者：
Wang, Chongjian
影响因子：
4.3
作者：
Martinez, Keilah E.;Tucker, Larry A.;LeCheminant, James D.
通讯作者：
LeCheminant, James D.
影响因子：
7.1
作者：
De Lorenzo, Antonino;Del Gobbo, Vera;Di Renzo, Laura
通讯作者：
Di Renzo, Laura
影响因子：
8.2
作者：
Han, Tianshu;Zhang, Shuang;Li, Ying
通讯作者：
Li, Ying