Chemosensory and hormone information are relayed directly between the medial amygdala, posterior bed nucleus of the stria terminalis, and medial preoptic area in male Syrian hamsters.
Chemosensory and hormone information are relayed directly between the medial amygdala, posterior bed nucleus of the stria terminalis, and medial preoptic area in male Syrian hamsters.
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DOI：
10.1016/j.yhbeh.2011.02.005
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发表时间：
2011-04
影响因子：
3.5
通讯作者：
Petrulis, Aras
中科院分区：
文献类型：
--
作者：
Been, Laura E.;Petrulis, Aras
在许多啮齿类动物中，包括叙利亚仓鼠，适当的社会行为的表达很大程度上取决于对同种气味的感知和识别。对这些气味的行为反应是由类固醇敏感的腹侧前脑核网络介导的，包括内侧杏仁核（Me）、终纹后床核（BNST）和内侧视前区（MPOA）。尽管众所周知，Me、BNST 和 MPOA 紧密相连，并且各自独特地调节气味引导的社会行为，但同种气味信息和类固醇激素线索在这些核之间直接传递的程度尚不清楚。为了回答这个问题，我们将逆行示踪剂霍乱毒素 B (CTB) 注射到男性受试者的 BNST 或 MPOA 中，并确定 Me 和 BNST 中逆行标记的细胞是否 1) 在暴露于男性和/或女性气味后表达立即早期基因 (IEG) 或 2) 表达雄激素受体 (AR)。尽管很少有逆行标记细胞与 IEG 共定位，但后 Me (MeP) 中的 BNST 和 MPOA 投射细胞在对女性气味的反应中表达 IEG 的比例高于对男性气味的反应。然而，在前 Me (MeA)、后中间 BNST (BNSTpi) 或后内侧 BNST (BNSTpm) 中，表达 IEG 的逆行标记细胞的百分比在女性和男性气味暴露组之间没有差异。许多逆行标记的细胞与 AR 共定位，逆行标记的 MeP 和 BNSTpm 细胞表达 AR 的比例分别高于逆行标记的 MeA 和 BNSTpi 细胞。这些数据共同表明，Me、BNST 和 MPOA 作为功能回路相互作用，处理雄性叙利亚仓鼠的性别特异性气味线索和激素信息。
In many rodent species, including Syrian hamsters, the expression of appropriate social behavior depends critically on the perception and identification of conspecific odors. The behavioral response to these odors is mediated by a network of steroid-sensitive ventral forebrain nuclei including the medial amygdala (Me), posterior bed nucleus of the stria terminalis (BNST) and medial preoptic area (MPOA). Although it is well-known that Me, BNST, and MPOA are densely interconnected and each uniquely modulates odor-guided social behaviors, the degree to which conspecific odor information and steroid hormone cues are directly relayed between these nuclei is unknown. To answer this question, we injected the retrograde tracer, cholera toxin B (CTB), into the BNST or MPOA of male subjects and identified whether retrogradely-labeled cells in Me and BNST 1) expressed immediate early genes (IEGs) following exposure to male and/or female odors or 2) expressed androgen receptor (AR). Although few retrogradely-labeled cells co-localized with IEGs, a higher percentage of BNST- and MPOA-projecting cells in the posterior Me (MeP) expressed IEGs in response to female odors than to male odors. The percentage of retrogradely-labeled cells that expressed IEGs did not, however, differ between and female- and male- odor-exposed groups in the anterior Me (MeA), posterointermediate BNST (BNSTpi), or posteromedial BNST (BNSTpm). Many retrogradely-labeled cells co-localized with AR, and a higher percentage of retrogradely-labeled MeP and BNSTpm cells expressed AR than retrogradely-labeled MeA and BNSTpi cells, respectively. Together, these data demonstrate that Me, BNST, and MPOA interact as a functional circuit to process sex-specific odor cues and hormone information in male Syrian hamsters.
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影响因子：
1.7
作者：
Delville, Y;De Vries, GJ;Ferris, CF
通讯作者：
Ferris, CF
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DELABRIL, A
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