Human pharyngeal microbiome may play a protective role in respiratory tract infections.
Human pharyngeal microbiome may play a protective role in respiratory tract infections.
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DOI：
10.1016/j.gpb.2014.06.001
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发表时间：
2014-06
影响因子：
9.5
通讯作者：
Ren, Lufeng
中科院分区：
文献类型：
--
作者：
Gao, Zhancheng;Kang, Yu;Yu, Jun;Ren, Lufeng
位于消化道和呼吸道交界处的人咽部微生物组可能在预防呼吸道感染方面发挥积极作用，类似于肠道微生物组对肠道感染的作用。最近的研究表明，咽部微生物组包含大量与局部上皮细胞和免疫细胞相互作用的细菌物种，它们共同形成了独特的微生态系统。微生物组中的大多数微生物物种是专性共生体，不断适应其独特的环境。土著入侵物种既能保持优势地位，又能激发宿主免疫反应，消灭入侵物种。由于局部上皮细胞受损而导致的咽部微生物组的暂时性损伤也被认为是感染的重要易感风险因素。因此，除了抗生素治疗和疫苗接种之外，加强微生物组稳态以防止易感染物种的入侵将提供一种新的治疗策略。因此，继续研究评估益生菌治疗和开发适当的程序对于预防和治疗呼吸道感染是必要的。
The human pharyngeal microbiome, which resides at the juncture of digestive and respiratory tracts, may have an active role in the prevention of respiratory tract infections, similar to the actions of the intestinal microbiome against enteric infections. Recent studies have demonstrated that the pharyngeal microbiome comprises an abundance of bacterial species that interacts with the local epithelial and immune cells, and together, they form a unique micro-ecological system. Most of the microbial species in microbiomes are obligate symbionts constantly adapting to their unique surroundings. Indigenous commensal species are capable of both maintaining dominance and evoking host immune responses to eliminate invading species. Temporary damage to the pharyngeal microbiome due to the impaired local epithelia is also considered an important predisposing risk factor for infections. Therefore, reinforcement of microbiome homeostasis to prevent invasion of infection-prone species would provide a novel treatment strategy in addition to antibiotic treatment and vaccination. Hence continued research efforts on evaluating probiotic treatment and developing appropriate procedures are necessary to both prevent and treat respiratory infections.
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影响因子：
3.7
作者：
Erb-Downward JR;Thompson DL;Han MK;Freeman CM;McCloskey L;Schmidt LA;Young VB;Toews GB;Curtis JL;Sundaram B;Martinez FJ;Huffnagle GB
通讯作者：
Huffnagle GB
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3.7
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11
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通讯作者：
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影响因子：
8.8
作者：
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通讯作者：
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影响因子：
--
作者：
GNARPE, J;LUNDBACK, A;GNARPE, H
通讯作者：
GNARPE, H