Interaction between BZR1 and PIF4 integrates brassinosteroid and environmental responses.
Interaction between BZR1 and PIF4 integrates brassinosteroid and environmental responses.
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DOI：
10.1038/ncb2545
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发表时间：
2012-08
影响因子：
21.3
通讯作者：
中科院分区：
文献类型：
--
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植物生长受环境和激素信号的协调调节。类维生素B1（BR）在光和温度对植物生长的调控中起着重要的作用，但BR与这些环境信号之间的相互作用在分子水平上的研究还很有限。在这里，我们表明，黑暗和热激活的转录因子光敏色素相互作用因子4（PIF 4）和BR激活的转录因子BZR 1之间的直接相互作用整合了激素和环境信号。BZR 1和PIF 4在体外和体内相互作用，结合近2000个共同的靶基因，并协同调节许多这些靶基因，包括促进细胞伸长所需的PRE家族HLH因子。遗传分析表明，BZR 1和PIFs是相互依赖的促进细胞伸长响应BR，黑暗，或热。这些结果表明BZR 1-PIF 4相互作用控制核心转录网络，允许类固醇和环境信号共同调节植物生长。
Plant growth is coordinately regulated by environmental and hormonal signals. Brassinosteroid (BR) plays essential roles in growth regulation by light and temperature, but the interactions between BR and these environmental signals remain poorly understood at the molecular level. Here, we show that direct interaction between the dark- and heat-activated transcription factor phytochrome-interacting factor4 (PIF4) and the BR-activated transcription factor BZR1 integrates the hormonal and environmental signals. BZR1 and PIF4 interact with each other in vitro and in vivo, bind to nearly two thousand common target genes, and synergistically regulate many of these target genes, including the PRE family HLH factors required for promoting cell elongation. Genetic analysis indicates that BZR1 and PIFs are interdependent in promoting cell elongation in response to BR, darkness, or heat. These results show that the BZR1-PIF4 interaction controls a core transcription network, allowing plant growth co-regulation by the steroid and environmental signals.
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