Associations between loneliness and personality are mostly driven by a genetic association with Neuroticism.
Associations between loneliness and personality are mostly driven by a genetic association with Neuroticism.
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DOI：
10.1111/jopy.12397
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发表时间：
2019-04
影响因子：
5
通讯作者：
Cacioppo JT
中科院分区：
文献类型：
--
作者：
Abdellaoui A;Chen HY;Willemsen G;Ehli EA;Davies GE;Verweij KJH;Nivard MG;de Geus EJC;Boomsma DI;Cacioppo JT
孤独是对理想的和实际的社会关系之间的差异的厌恶反应，与人格相关。本研究以双生子家庭为研究对象，结合分子遗传学资料，探讨孤独与人格的关系。在29，625名成年人中估计了孤独感与大五人格特质之间的表型相关性，并在一组全基因组基因型数据（N= 4，222）中获得了遗传相关性。我们通过研究同卵双生子内的差异（N对= 2，662），人格和孤独的纵向受试者内变化（N= 4，260 - 9，238纵向比较）以及纵向交叉滞后面板分析（N= 15，628）来探索遗传相关性是否可以反映因果关系。最后，我们测试了遗传相关性是否是由于交叉性状选择性交配（N配偶对= 4，436）。与孤独感相关性最强的是神经质（r= 0.55）和外向性（r=-0.33）。只有神经质表现出独立于其他人格特质的孤独感的高相关性（r= 0.50），因此后续分析集中在神经质上。孤独和神经质的基因型变异之间的遗传相关性为0.71;一个显着的相互因果关系和非显着的跨性状交配意味着，这至少部分是由于介导的多效性。我们发现，孤独和人格之间的关系在很大程度上是由它与神经质，这是本质上遗传的关系解释。
Loneliness is an aversive response to a discrepancy between desired and actual social relationships and correlates with personality. We investigate the relationship of loneliness and personality in twin-family and molecular genetic data. Phenotypic correlations between loneliness and the Big Five personality traits were estimated in 29,625 adults, and in a group with genome-wide genotype data (N=4,222), genetic correlations were obtained. We explored whether genetic correlations may reflect causal relationships by investigating within monozygotic twin-pair differences (Npairs=2,662), by longitudinal within-subject changes in personality and loneliness (N=4,260–9,238 longitudinal comparisons), and by longitudinal cross-lagged panel analyses (N=15,628). Finally, we tested whether genetic correlations were due to cross-trait assortative mating (Nspouse-pairs=4,436). The strongest correlations with loneliness were observed for neuroticism (r=.55) and extraversion (r=−.33). Only neuroticism showed a high correlation with loneliness independent of other personality traits (r=.50), so follow-up analyses focused on neuroticism. The genetic correlation between loneliness and neuroticism from genotyped variants was .71; a significant reciprocal causal relationship and non-significant cross-trait assortative mating imply that this is at least partly due to mediated pleiotropy. We show that the relationship between loneliness and personality is largely explained by its relationship with neuroticism, which is substantially genetic in nature.
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影响因子：
2.6
作者：
Abdellaoui, Abdel;Hottenga, Jouke-Jan;Xiao, Xiangjun;Scheet, Paul;Ehli, Erik A.;Davies, Gareth E.;Hudziak, James J.;Smit, Dirk J. A.;Bartels, Meike;Willemsen, Gonneke;Brooks, Andrew;Sullivan, Patrick F.;Smit, Johannes H.;de Geus, Eco J.;Penninx, Brenda W. J. H.;Boomsma, Dorret I.
通讯作者：
Boomsma, Dorret I.
影响因子：
19.9
作者：
Cacioppo, John T.;Hawkey, Louise C.
通讯作者：
Hawkey, Louise C.
影响因子：
24.8
作者：
Cacioppo JT;Cacioppo S;Capitanio JP;Cole SW
通讯作者：
Cole SW
影响因子：
7.6
作者：
DeYoung, Colin G.
通讯作者：
DeYoung, Colin G.
影响因子：
--
作者：
De Moor, Marleen H. M.;Boomsma, Dorret I.;de Geus, Eco J. C.
通讯作者：
de Geus, Eco J. C.