Targeting the Microbiota, from Irritable Bowel Syndrome to Mood Disorders: Focus on Probiotics and Prebiotics.
Targeting the Microbiota, from Irritable Bowel Syndrome to Mood Disorders: Focus on Probiotics and Prebiotics.
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DOI：
10.1007/s40139-018-0160-3
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发表时间：
2018-03
影响因子：
--
通讯作者：
Gareau MG
中科院分区：
文献类型：
--
作者：
Pusceddu MM;Murray K;Gareau MG
肠道和大脑之间的串扰揭示了一个复杂的通信系统，负责维持适当的胃肠道稳态，以及影响情绪和认知功能。最近的研究表明，益生菌和益生元对微生物群的有益操纵代表了一种新兴的新策略，用于治疗从内脏疼痛到情绪障碍的各种疾病。该综述批判性地评估了益生菌和益生元在肠易激综合征（IBS）和焦虑和抑郁等情绪障碍中的作用。通过PubMed检索MEDLINE，使用以下词语“益生菌”、“益生元”、“微生物群”和“肠-脑轴”以及“压力”、“抑郁”、“IBS”和“焦虑”识别相关文献。许多试验已经显示益生菌和益生元在改善IBS相关症状和情绪状态方面的功效。然而，由于临床研究数量少、研究设计、患者样本量和安慰剂效应，发现了局限性。尽管如此，目前的发现支持这样的观点，即通过益生菌和益生元摄入对微生物群进行有益的操纵代表了治疗肠-脑轴疾病如IBS和抑郁症的一种新的有吸引力的策略。
The crosstalk between the gut and the brain has revealed a complex communication system responsible for maintaining a proper gastrointestinal homeostasis as well as affect emotional mood and cognitive functions. Recent research has revealed that beneficial manipulation of the microbiota by probiotics and prebiotics represent an emerging and novel strategy for the treatment of a large spectrum of diseases ranging from visceral pain to mood disorders. The review critically evaluates current knowledge of the effects exerted by both probiotics and prebiotics in irritable bowel syndrome (IBS) and mood disorders such as anxiety and depression. Relevant literature was identified through a search of MEDLINE via PubMed using the following words, “probiotics”, “prebiotics”, “microbiota”, and “gut-brain axis” in combination with “stress”, “depression”, “IBS”, and “anxiety”. A number of trials have shown efficacy of probiotics and prebiotics in ameliorating both IBS related symptoms and emotional states. However, limitations have been found especially due to the small number of clinical studies, studies design, patient sample size, and placebo effect. Nonetheless, current finding supports the view that beneficial manipulation of the microbiota through both probiotics and prebiotics intake represents a novel attractive strategy to treat gut-brain axis disorders such as IBS and depression.
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影响因子：
8
作者：
Francavilla, Ruggiero;Miniello, Vito;Cavallo, Luciano
通讯作者：
Cavallo, Luciano
DOI：
10.1097/mpg.0b013e3181ca4d95
发表时间：
2010-07-01
影响因子：
2.9
作者：
Guandalini, Stefano;Magazzu, Giuseppe;Setty, Mala
通讯作者：
Setty, Mala
DOI：
10.1038/nrgastro.2010.117
发表时间：
2010-09
期刊：
Nature reviews. Gastroenterology & hepatology
影响因子：
--
作者：
Gareau MG;Sherman PM;Walker WA
通讯作者：
Walker WA
影响因子：
7.6
作者：
Guyonnet, D.;Chassany, O.;Matuchansky, C.
通讯作者：
Matuchansky, C.
影响因子：
24.5
作者：
Gareau, Melanie G.;Jury, Jennifer;Perdue, Mary H.
通讯作者：
Perdue, Mary H.