Health Disparities in COVID-19: Addressing the Role of Social Determinants of Health in Immune System Dysfunction to Turn the Tide.
Health Disparities in COVID-19: Addressing the Role of Social Determinants of Health in Immune System Dysfunction to Turn the Tide.
复制标题
DOI：
10.3389/fpubh.2020.559312
复制
发表时间：
2020
影响因子：
5.2
通讯作者：
Powell-Wiley TM
中科院分区：
文献类型：
--
作者：
Baumer Y;Farmer N;Premeaux TA;Wallen GR;Powell-Wiley TM
在新型冠状病毒SARS-CoV-2引起的COVID-19大流行期间，健康差距显然存在。COVID-19健康差异的根本原因是多因素的。然而，社会决定因素，包括那些关于社会经济地位，社会不平等，健康行为和压力，可能会影响这些差异。暴露于这些社会决定因素中的一种或多种与炎症反应的增强，特别是细胞因子白细胞介素-6（IL-6）的增加以及免疫系统功能障碍有关。因此，在COVID-19期间可能会发生放大效应，可能导致脆弱的患者由于过度活跃和功能失调的免疫反应而经历强化的细胞因子风暴。进一步了解社会决定因素如何在COVID-19差异中发挥机械作用，可能有助于减少整体健康差异和未来流行病的健康差异。
It is evident that health disparities exist during the COVID-19 pandemic, a pandemic caused by the novel coronavirus SARS-CoV-2. Underlying reasons for COVID-19 health disparities are multi-factorial. However, social determinants, including those regarding socioeconomic status, social inequalities, health behaviors, and stress, may have implications on these disparities. Exposure to one or more of these social determinants is associated with heightened inflammatory responses, particularly increases in the cytokine interleukin-6 (IL-6), as well as immune system dysfunction. Thus, an amplified effect during COVID-19 could occur, potentially resulting in vulnerable patients experiencing an intensified cytokine storm due to a hyperactive and dysfunctional immune response. Further understanding how social determinants play a mechanistic role in COVID-19 disparities could potentially help reduce health disparities overall and in future pandemics.
登录
查看更多内容
DOI：
10.1038/npp.2010.159
发表时间：
2010-12
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
通讯作者：
--
影响因子：
8.8
作者：
Anekwe, Chika Vera;Jarrell, Amber R.;Stanford, Fatima Cody
通讯作者：
Stanford, Fatima Cody
影响因子：
7.6
作者：
Brody, Gene H.;Yu, Tianyi;Chen, Edith
通讯作者：
Chen, Edith
在老年人中，与皮质醇升高和穿孔素表达减少相关的心理压力而非身体压力会增加 NK 细胞免疫衰老。
影响因子：
--
作者：
Duggal, Niharika Arora;Upton, Jane;Phillips, Anna C.;Hampson, Peter;Lord, Janet M.
通讯作者：
Lord, Janet M.
结构性种族主义，社会危险因素和共同-19-对黑人美国人的危险融合。
DOI：
10.1056/nejmp2023616
发表时间：
2020-09-17
期刊：
The New England journal of medicine
影响因子：
--
作者：
Egede LE;Walker RJ
通讯作者：
Walker RJ