NK cell immunesenescence is increased by psychological but not physical stress in older adults associated with raised cortisol and reduced perforin expression.
NK cell immunesenescence is increased by psychological but not physical stress in older adults associated with raised cortisol and reduced perforin expression.
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在老年人中，与皮质醇升高和穿孔素表达减少相关的心理压力而非身体压力会增加 NK 细胞免疫衰老。
DOI：
10.1007/s11357-015-9748-2
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发表时间：
2015-02
期刊：
影响因子：
--
通讯作者：
Lord, Janet M.
中科院分区：
文献类型：
--
作者：
Duggal, Niharika Arora;Upton, Jane;Phillips, Anna C.;Hampson, Peter;Lord, Janet M.
NK细胞毒性（NKCC）随着年龄的增长而降低，这与先前的死亡率增加有关。免疫反应也受到压力的调节，在这里，我们评估了髋部骨折的物理压力和抑郁的心理压力对老年免疫系统中NKCC的影响。在101例髋部骨折患者（81名女性）受伤后6周和6个月以及50名年龄匹配的健康对照组（28名女性）中评估了NKCC。38例患者在损伤后6周出现抑郁，与非抑郁髋部骨折患者（p = 0.004）或对照组（p < 0.02）相比，出现抑郁的患者的NKCC减少。骨折后6个月，抑郁症患者的NKCC仍低于无抑郁症患者（p = 0.017）。我们发现，骨折后6周，与对照组相比，抑郁症髋部骨折患者NK细胞中穿孔素的表达降低（p = 0.001）。与非抑郁症患者相比，抑郁症患者血清皮质醇水平在6周（p = 0.01）和6个月（p = 0.05）时也有所升高。地塞米松处理的NK细胞显示NKCC和穿孔素表达的浓度依赖性降低。我们认为抑郁是影响髋部骨折后NK细胞免疫的主要因素。
NK cell cytotoxicity (NKCC) reduces with age and this has been associated previously with increased mortality. The immune response is also modulated by stress, and here, we assessed the effect of the physical stress of hip fracture and the psychological stress of depression on NKCC in an aged immune system. NKCC was assessed in 101 hip fracture patients (81 female) 6 weeks and 6 months after injury and in 50 healthy age-matched controls (28 female). Thirty-eight patients were depressed at 6 weeks post-injury, and NKCC was reduced in patients who developed depression compared with non-depressed hip fracture patients (p = 0.004) or controls (p < 0.02). NKCC remained lower in the depressed patients compared to those without depression 6 months post-fracture (p = 0.017). We found reduced expression of perforin in NK cells of depressed hip fracture patients compared with controls at 6 weeks (p = 0.001) post-fracture. Serum cortisol levels were also elevated in patients with depression compared to non-depressed patients at 6 weeks (p = 0.01) and 6 months (p = 0.05). NK cells treated with dexamethasone showed a concentration-dependent reduction in NKCC and perforin expression. We propose that depression is the major factor affecting NK cell immunity after hip fracture.
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影响因子：
3.3
作者：
Esterling, BA;KiecoltGlaser, JK;Glaser, R
通讯作者：
Glaser, R
影响因子：
11.3
作者：
DARKO, DF;LUCAS, AH;JANOWSKY, DS
通讯作者：
JANOWSKY, DS
影响因子：
3.9
作者：
Borrego, F;Alonso, MC;Solana, R
通讯作者：
Solana, R
影响因子：
7.8
作者：
Butcher, SK;Killampalli, V;Lord, JM
通讯作者：
Lord, JM
DOI：
10.1016/j.jsbmb.2009.12.016
发表时间：
2010-05-31
影响因子：
4.1
作者：
Hazeldine, Jon;Arlt, Wiebke;Lord, Janet M.
通讯作者：
Lord, Janet M.