The anaemia of Plasmodium vivax malaria.

The anaemia of Plasmodium vivax malaria.
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DOI:
10.1186/1475-2875-11-135
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发表时间:
2012-04-27
期刊:
影响因子:
3
通讯作者:
Price RN
Price RN
中科院分区:
医学3区
文献类型:
--
作者:
Douglas NM;Anstey NM;Buffet PA;Poespoprodjo JR;Yeo TW;White NJ;Price RN

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间日疟原虫威胁着世界近一半的人口,是实现千年发展目标的一个重大障碍。它是贫血的一个重要原因,但尚未完全了解。本文综述了间日疟原虫相关贫血的流行病学、发病机制、治疗和后果方面的最新证据。幼儿患具有临床意义和可能严重的间日疟相关贫血的风险很高,特别是在传播剧烈和复发频繁的国家。尽管间日疟原虫的密度低于恶性疟原虫,但间日疟原虫造成的红细胞数量的绝对减少与恶性疟原虫相似,因为间日疟原虫导致未感染的红细胞按比例被更多地清除。严重间日贫血与大量间接死亡率和发病率相关,原因是对合并症、产科并发症和输血需求的抵御能力受损。通过早期和有效的抗疟疾治疗可以避免贫血。
Plasmodium vivax threatens nearly half the world’s population and is a significant impediment to achievement of the millennium development goals. It is an important, but incompletely understood, cause of anaemia. This review synthesizes current evidence on the epidemiology, pathogenesis, treatment and consequences of vivax-associated anaemia. Young children are at high risk of clinically significant and potentially severe vivax-associated anaemia, particularly in countries where transmission is intense and relapses are frequent. Despite reaching lower densities than Plasmodium falciparum, Plasmodium vivax causes similar absolute reduction in red blood cell mass because it results in proportionately greater removal of uninfected red blood cells. Severe vivax anaemia is associated with substantial indirect mortality and morbidity through impaired resilience to co-morbidities, obstetric complications and requirement for blood transfusion. Anaemia can be averted by early and effective anti-malarial treatment.
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