Tea consumption and colorectal cancer risk: a meta-analysis of prospective cohort studies
Tea consumption and colorectal cancer risk: a meta-analysis of prospective cohort studies
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茶叶消费与结直肠癌风险：前瞻性队列研究的荟萃分析
DOI：
10.1007/s00394-020-02195-3
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发表时间：
2020-02
影响因子：
5
通讯作者：
Zhong‑hua Liu
中科院分区：
文献类型：
--
作者：
Ming‑zhi Zhu;Dan‑min Lu;Jian Ouyang;Fang Zhou;Pei‑fang Huang;Bao‑zheng Gu;Jun‑wei Tang;Fan Shen;Jia‑feng Li;Yi‑long Li;Hai‑yan Lin;Juan Li;Xin Zeng;Jian‑lin Wu;Shu‑xian Cai;Kun‑bo Wang;Jian‑an Huang;Zhong‑hua Liu
目的体外和动物实验数据支持茶汤对结直肠癌的预防作用。此外，许多流行病学研究评估了饮茶与结直肠癌风险之间的关系，但结果并不一致。我们对前瞻性队列研究进行了Meta分析，以系统地评估饮茶与结直肠癌风险之间的关系。方法通过检索PubMed和Embase，检索相关文献，直至2019年6月。采用固定效应模型计算汇总相对危险度(RR)和95%可信区间(CI)。结果本研究共纳入20篇队列文章，涉及2,068,137名参与者和21,437例患者。在所有研究中，最高饮茶量与最低饮茶量的结直肠癌合并RR为0.97(95%CI 为0.94~1.01)，边缘异质性(I2= 24.0%，P= 0.093)。这表明饮茶与结直肠癌风险没有显著关联。分层分析显示，各亚组间差异无统计学意义。我们进一步进行了特定性别的元分析，以得出更准确的估计。未发现男性饮茶与结直肠癌风险显著相关(合并RR = 为0.97；95%CI 为0.90-1.04)。然而，饮茶对女性结直肠癌风险的边际显著负影响(合并RR = 为0.93；95%CI 为0.86-1.00)。此外，我们发现，在没有调整咖啡摄入量的女性研究中(RR：0.9；95%CI 0.82-1.00，P<； 0.05)，与调整咖啡摄入量的女性研究(RR=0.97；95%CI 0.87-1.09，P>；结论我们的研究结果表明，饮茶对男女结直肠癌风险没有显著影响，但特定性别的荟萃分析显示，饮茶对女性结直肠癌风险的影响微乎其微。
PurposeData from in vitro and animal studies support the preventive effect of tea (Camellia sinensis) against colorectal cancer. Further, many epidemiologic studies evaluated the association between tea consumption and colorectal cancer risk, but the results were inconsistent. We conducted a meta-analysis of prospective cohort studies to systematically assess the association between tea consumption and colorectal cancer risk.MethodsA comprehensive literature review was conducted to identify the related articles by searching PubMed and Embase up to June, 2019. Summary relative risks (RRs) and 95% confidence intervals (CIs) were calculated using a fixed effect model.ResultsTwenty cohort articles were included in the present meta-analysis involving 2,068,137 participants and 21,437 cases. The combined RR of colorectal cancer for the highest vs. lowest tea consumption was determined to 0.97 (95% CI 0.94–1.01) with marginal heterogeneity (I2= 24.0%,P= 0.093) among all studies. This indicated that tea consumption had no significant association with colorectal cancer risk. Stratified analysis showed that no significant differences were found in all subgroups. We further conducted the gender-specific meta-analysis for deriving a more precise estimation. No significant association was observed between tea consumption and colorectal cancer risk in male (combined RR = 0.97; 95% CI 0.90–1.04). However, tea consumption had a marginal significant inverse impact on colorectal cancer risk in female (combined RR = 0.93; 95% CI 0.86–1.00). Further, we found a stronger inverse association between tea consumption and risk of colorectal cancer among the female studies with no adjustment of coffee intake (RR: 0.90; 95% CI 0.82–1.00,P< 0.05) compared to the female studies that adjusted for coffee intake (RR = 0.97; 95% CI 0.87–1.09,P> 0.05).ConclusionsOur finding indicates that tea consumption has no significant impact on the colorectal cancer risk in both genders combined, but gender-specific meta-analysis shows that tea consumption has a marginal significant inverse impact on colorectal cancer risk in female.
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影响因子：
8.8
作者：
Dominianni C;Huang WY;Berndt S;Hayes RB;Ahn J
通讯作者：
Ahn J
DOI：
10.1207/s15327914nc392_3
发表时间：
2001-03
期刊：
Nutrition and Cancer
影响因子：
--
作者：
Paul Terry;A. Wolk
通讯作者：
Paul Terry;A. Wolk
影响因子：
10.3
作者：
Goldbohm, RA;Hertog, MGL;vandenBrandt, PA
通讯作者：
vandenBrandt, PA
影响因子：
5
作者：
Zheng, W;Doyle, TJ;Folsom, AR
通讯作者：
Folsom, AR
影响因子：
2.9
作者：
Nakagawa, K;Miyazawa, T
通讯作者：
Miyazawa, T