Vitamin D Deficiency During Development Permanently Alters Liver Cell Composition and Function.
Vitamin D Deficiency During Development Permanently Alters Liver Cell Composition and Function.
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发育过程中缺乏维生素D会永久性地改变肝细胞的组成和功能。
DOI：
10.3389/fendo.2022.860286
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发表时间：
2022
影响因子：
5.2
通讯作者：
Suzuki, Masako
中科院分区：
文献类型：
--
作者：
Lundy, Kassidy;Greally, John F.;Essilfie-Bondzie, Grace;Olivier, Josephine B.;Dona-Termine, Reanna;Greally, John M. M.;Suzuki, Masako
关键词：
维生素D是一种脂溶性维生素，在钙稳态、免疫系统和正常发育中起着关键作用。全球许多流行病学队列研究发现，维生素D缺乏和不足的患病率很高，被认为是一个需要解决的重要健康问题。特别是，育龄妇女和维生素D水平低的孕妇可能会给后代带来肥胖等疾病的风险。虽然观察性研究表明产前维生素D缺乏症与后代的代谢表型之间存在关联，但尚未确定产前维生素D缺乏症是否会永久改变肝脏（一个主要代谢器官）的发育。我们测试了雄性C57 BL/6 J小鼠暴露于产前维生素D缺乏症通过母体饮食干预模型的肝脏的组织病理学和转录谱。我们发现，产前维生素D缺乏症会增加肝脏组织病理学变化的患病率，并改变其基因表达谱。细胞亚型比例分析表明，产前维生素D缺乏症的肝脏改变了肝脏的非实质细胞，特别是巨噬细胞，内皮细胞和树突状细胞的子集。我们的研究结果表明，产前维生素D缺乏暴露在成人肝脏的长期记忆，一个潜在的贡献者后代的健康风险。
Vitamin D, a fat-soluble vitamin, plays a critical role in calcium homeostasis, the immune system, and normal development. Many epidemiological cohort studies globally have found high prevalence rates of vitamin D deficiency and insufficiency, recognized as an important health issue that needs to be solved. In particular, reproductive age and pregnant women low in vitamin D status may confer risks of diseases like obesity on their offspring. While observational studies have suggested associations between prenatal vitamin D deficiency and metabolic phenotypes in offspring, not yet determined is whether prenatal vitamin D deficiency permanently alters the development of the liver, a major metabolic organ. We tested the histopathology and the transcriptomic profiles of livers from male C57BL/6J mice exposed to prenatal vitamin D deficiency through a maternal dietary intervention model. We found that prenatal vitamin D deficiency increases the prevalence of histopathological changes in the liver, and alters its gene expression profile. Cell subtype proportion analysis showed that the liver of prenatal vitamin D deficiency alters non-parenchymal cells of the liver, specifically macrophages, a subset of endothelial cells, and dendritic cells. Our results indicate the long-term memory of prenatal vitamin D deficiency exposure in the adult liver, a potential contributor to offspring health risks.
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影响因子：
4.7
作者：
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通讯作者：
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影响因子：
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