Reward processing in autism.
Reward processing in autism.
复制标题
DOI：
10.1002/aur.122
复制
发表时间：
2010-04
期刊：
影响因子：
4.7
通讯作者：
Bookheimer, Susan Y.
中科院分区：
文献类型：
--
作者：
Scott-Van Zeeland, Ashley A.;Dapretto, Mirella;Ghahremani, Dara G.;Poldrack, Russell A.;Bookheimer, Susan Y.
自闭症的社会动机假说认为，自闭症婴儿不会将社会刺激视为奖励，从而导致对以后发展的潜在负面影响。虽然这一假设可能的下游效应，如改变面部和声音处理已被检查，还没有直接调查自闭症的社会奖励处理。在这里，我们使用功能磁共振成像检查社会和金钱奖励的内隐学习儿童和非自闭症谱系障碍（ASD）。16名ASD男性和16名年龄和智商匹配的典型发育（TD）男性进行了扫描，同时执行两个版本的奖励内隐学习任务。除了研究对奖励的反应，我们还研究了支持奖励学习的神经回路以及这些因素与社会发展之间的关系。我们发现ASD患者对社会和金钱奖励的神经反应减弱，对社会奖励（SR）的反应明显减少。ASD儿童在社会奖励学习中也表现出额纹状体反应的进一步缺陷，但不是金钱奖励学习。此外，我们表明腹侧纹状体活动和社会互惠TD儿童之间的关系。总之，这些数据支持这一假设，即ASD儿童对SR的神经反应减弱，并且这种缺陷与社会学习障碍有关。
The social motivation hypothesis of autism posits that infants with autism do not experience social stimuli as rewarding, thereby leading to a cascade of potentially negative consequences for later development. While possible downstream effects of this hypothesis such as altered face and voice processing have been examined, there has not been a direct investigation of social reward processing in autism. Here we use functional magnetic resonance imaging to examine social and monetary rewarded implicit learning in children with and without autism spectrum disorders (ASD). Sixteen males with ASD and sixteen age- and IQ-matched typically developing (TD) males were scanned while performing two versions of a rewarded implicit learning task. In addition to examining responses to reward, we investigated the neural circuitry supporting rewarded learning and the relationship between these factors and social development. We found diminished neural responses to both social and monetary rewards in ASD, with a pronounced reduction in response to social rewards (SR). Children with ASD also demonstrated a further deficit in frontostriatal response during social, but not monetary, rewarded learning. Moreover, we show a relationship between ventral striatum activity and social reciprocity in TD children. Together, these data support the hypothesis that children with ASD have diminished neural responses to SR, and that this deficit relates to social learning impairments.
登录
查看更多内容
影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S
影响因子：
4.8
作者：
Knutson, B;Cooper, JC
通讯作者：
Cooper, JC
影响因子：
3.9
作者：
Constantino, JN;Davis, SA;Reich, W
通讯作者：
Reich, W
影响因子：
10.6
作者：
Langen, Marieke;Durston, Sarah;van Engeland, Herman
通讯作者：
van Engeland, Herman
影响因子：
2.9
作者：
LEVY, F;KENDRICK, KM;KEVERNE, EB
通讯作者：
KEVERNE, EB