To adhere or not to adhere: the role of Cadherins in neural crest development.
To adhere or not to adhere: the role of Cadherins in neural crest development.
复制标题
DOI：
10.4161/cam.2.4.6835
复制
发表时间：
2008-10
影响因子：
3.2
通讯作者：
Taneyhill LA
中科院分区：
文献类型：
--
作者：
Taneyhill LA
细胞粘附的调节是伴随胚胎正常发育的形态发生的基础。钙粘蛋白是钙依赖性细胞粘附分子的一个大家族，其空间和时间表达对于神经嵴的形成至关重要，神经嵴是一种独特的多能细胞类型，有助于脊椎动物身体计划的形成。神经嵴细胞通过诱导相互作用从胚胎外胚层产生，并驻留在神经管的背面。这些细胞经历上皮到间质的转变，并迁移到胚胎中的精确目的地，在那里它们继续分化成多种结构，如黑素细胞、周围神经系统的元件和颅面骨骼。不同的钙粘蛋白在神经嵴的诱导、迁移和分化过程中表达。随着各种模式生物的基因组测序、组装和注释的出现，阐明钙粘蛋白表达的分子机制以及这些钙粘蛋白在神经嵴发育过程中如何发挥作用已经成为可能。本综述探讨了钙粘蛋白的已知作用，并详细介绍了不同钙粘蛋白在神经嵴形成过程中如何受到调节。
The modulation of cell adhesion is fundamental to the morphogenesis that accompanies proper embryonic development. Cadherins are a large family of calcium-dependent cell adhesion molecules whose spatial and temporal expression is critical to the formation of the neural crest, a unique, multipotent cell type that contributes to the patterning of the vertebrate body plan. Neural crest cells arise from the embryonic ectoderm through inductive interactions and reside in the dorsal aspect of the neural tube. These cells under go an epithelial-to-mesenchymal transition and migrate to precise destinations in the embryo, where they go on to differentiate into such diverse structures as melanocytes, elements of the peripheral nervous system, and the craniofacial skeleton. Distinct cadherins are expressed during the induction, migration and differentiation of the neural crest. With the advent of genomic sequencing, assembly and annotation for various model organisms, it has become possible to elucidate the molecular mechanisms underlying cadherin expression, and how these cadherins function, during neural crest development. This review explores the known roles of cadherins and details, where relevant, how different cadherins are regulated during the formation of the neural crest.
登录
查看更多内容
影响因子：
2.7
作者：
KIMURA, Y;MATSUNAMI, H;TAKEICHI, M
通讯作者：
TAKEICHI, M
DOI：
10.1073/pnas.80.14.4384
发表时间：
1983-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
EDELMAN, GM;GALLIN, WJ;THIERY, JP
通讯作者：
THIERY, JP
影响因子：
3.5
作者：
Faulkner-Jones, BE;Godinho, LNM;Tan, SS
通讯作者：
Tan, SS
影响因子：
2.7
作者：
BRONNERFRASER, M;WOLF, JJ;MURRAY, BA
通讯作者：
MURRAY, BA
影响因子：
4.6
作者：
Burstyn-Cohen, T;Stanleigh, J;Kalcheim, C
通讯作者：
Kalcheim, C