Chronic exposure to high levels of particulate air pollution and small airway remodeling.
Chronic exposure to high levels of particulate air pollution and small airway remodeling.
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DOI：
10.1289/ehp.6042
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发表时间：
2003-05
影响因子：
10.4
通讯作者：
Wright JL
中科院分区：
文献类型：
--
作者：
Churg A;Brauer M;del Carmen Avila-Casado M;Fortoul TI;Wright JL
最近的证据表明，长期暴露于高水平的环境颗粒物（PM）与肺功能下降和慢性气流阻塞的发展有关。为了研究PM诱导的小气道异常在这些功能改变中的可能作用，我们检查了来自墨西哥城（PM高地区）的20名妇女的肺组织切片。所有受试者都是墨西哥城的终身居民，从不吸烟，从未接触过职业性粉尘，从未使用生物质燃料烹饪。来自加拿大不列颠哥伦比亚省温哥华低PM地区的20名从不吸烟、无粉尘暴露的受试者作为对照。光镜下，墨西哥城肺中可见异常的小气道，有纤维化壁和多余的肌肉，其中许多含有可见的灰尘。正式的分级分析证实，与温哥华的肺相比，墨西哥城的气道壁中存在大量的纤维组织和肌肉。来自墨西哥城的4例病例的电子显微镜颗粒负荷测量显示，气道粘膜中存在超细颗粒的碳质聚集体，聚集体可能是燃烧产物。我们的结论是，PM进入并保留在小气道壁上，即使在不吸烟者中，长期暴露于高水平的环境颗粒污染物也与小气道重塑有关。这个过程可能产生慢性气流阻塞。
Recent evidence suggests that chronic exposure to high levels of ambient particulate matter (PM) is associated with decreased pulmonary function and the development of chronic airflow obstruction. To investigate the possible role of PM-induced abnormalities in the small airways in these functional changes, we examined histologic sections from the lungs of 20 women from Mexico City, a high PM locale. All subjects were lifelong residents of Mexico City, were never-smokers, never had occupational dust exposure, and never used biomass fuel for cooking. Twenty never-smoking, non-dust-exposed subjects from Vancouver, British Columbia, Canada, a low PM region, were used as a control. By light microscopy, abnormal small airways with fibrotic walls and excess muscle, many containing visible dust, were present in the Mexico City lungs. Formal grading analysis confirmed the presence of significantly greater amounts of fibrous tissue and muscle in the walls of the airways in the Mexico City compared with the Vancouver lungs. Electron microscopic particle burden measurements on four cases from Mexico City showed that carbonaceous aggregates of ultrafine particles, aggregates likely to be combustion products, were present in the airway mucosa. We conclude that PM penetrates into and is retained in the walls of small airways, and that, even in nonsmokers, long-term exposure to high levels of ambient particulate pollutants is associated with small airway remodeling. This process may produce chronic airflow obstruction.
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影响因子：
10.4
作者：
Dockery, DW
通讯作者：
Dockery, DW
影响因子：
10.4
作者：
Pinkerton, KE;Green, FHY;Schenker, MB
通讯作者：
Schenker, MB
DOI：
10.1164/ajrccm/136.2.271
发表时间：
1987-08-01
期刊：
AMERICAN REVIEW OF RESPIRATORY DISEASE
影响因子：
--
作者：
TRON, V;WRIGHT, JL;CHURG, A
通讯作者：
CHURG, A
DOI：
10.1164/ajrccm.158.1.9710101
发表时间：
1998-07-01
影响因子：
24.7
作者：
Abbey, DE;Burchette, RJ;Enright, PL
通讯作者：
Enright, PL
DOI：
10.1080/10473289.1997.10464407
发表时间：
1997-01-01
影响因子：
2.7
作者：
Brook, JR;Dann, TF;Burnett, RT
通讯作者：
Burnett, RT