SARS-CoV-2 infection and pulmonary tuberculosis in children and adolescents: a case-control study.
SARS-CoV-2 infection and pulmonary tuberculosis in children and adolescents: a case-control study.
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DOI：
10.1186/s12879-023-08412-8
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发表时间：
2023-06-29
影响因子：
3.7
通讯作者：
Seddon, James A. A.
中科院分区：
文献类型：
--
作者：
Swanepoel, Jeremi;van der Zalm, Marieke M. M.;Preiser, Wolfgang;van Zyl, Gert;Whittaker, Elizabeth;Hesseling, Anneke C. C.;Moore, David A. J.;Seddon, James A. A.
严重急性呼吸道综合征-冠状病毒-2（SARS-CoV-2）大流行对全球结核病（TB）流行产生了影响，但关于SARS-CoV-2与结核病（尤其是儿童和青少年）之间可能相互作用的证据仍然有限。我们的目的是评估先前感染SARS-CoV-2与儿童和青少年结核病风险之间的关系。2020年11月至2021年11月，在南非开普敦，使用两项观察性结核病研究（青少年结核病和Umoya）招募的未接种SARS-CoV-2疫苗的儿童和青少年进行了一项不匹配的病例对照研究。64名肺结核患者（年龄< 20岁）和99名非肺结核患者（年龄< 20岁）被纳入研究。获得人口统计学和临床数据。使用Abbott SARS-CoV-2 IgG II Quant检测试剂盒对入组时采集的血清样本进行定量SARS-CoV-2抗刺突免疫球蛋白G（IgG）检测。使用非条件Logistic回归估计TB的比值比（OR）。在SARS-CoV-2 IgG血清阳性和血清阴性患者之间，肺结核的几率没有统计学显著差异（调整OR 0.51; 95%CI：0.23-1.11; n = 163; p = 0.09）。在SARS-CoV-2血清学阳性的患者中，结核病患者的基线IgG滴度高于非结核病患者（p = 0.04），IgG滴度最高的三分位数患者比IgG水平最低的三分位数患者更可能患有肺结核（OR：4.00; 95%CI：1.13- 14.21; p = 0.03）。我们的研究没有发现令人信服的证据表明SARS-CoV-2血清阳性与随后的肺结核疾病相关;然而，SARS-CoV-2 IgG应答的幅度与肺结核之间的关联值得进一步研究。未来的前瞻性研究，评估性别，年龄和青春期对宿主免疫反应的影响。结核病和SARS-CoV-2的研究也将更清楚地说明这两种感染之间的相互作用。在线版本包含补充材料，可通过10.1186/s12879-023-08412-8获得。
The Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) pandemic has had an impact on the global tuberculosis (TB) epidemic but evidence on the possible interaction between SARS-CoV-2 and TB, especially in children and adolescents, remains limited. We aimed to evaluate the relationship between previous infection with SARS-CoV-2 and the risk of TB in children and adolescents. An unmatched case-control study was conducted using SARS-CoV-2 unvaccinated children and adolescents recruited into two observational TB studies (Teen TB and Umoya), between November 2020 and November 2021, in Cape Town, South Africa. Sixty-four individuals with pulmonary TB (aged < 20 years) and 99 individuals without pulmonary TB (aged < 20 years) were included. Demographics and clinical data were obtained. Serum samples collected at enrolment underwent quantitative SARS-CoV-2 anti-spike immunoglobulin G (IgG) testing using the Abbott SARS-CoV-2 IgG II Quant assay. Odds ratios (ORs) for TB were estimated using unconditional logistic regression. There was no statistically significant difference in the odds of having pulmonary TB between those who were SARS-CoV-2 IgG seropositive and those who were seronegative (adjusted OR 0.51; 95% CI: 0.23–1.11; n = 163; p = 0.09). Of those with positive SARS-CoV-2 serology indicating prior infection, baseline IgG titres were higher in individuals with TB compared to those without TB (p = 0.04) and individuals with IgG titres in the highest tertile were more likely to have pulmonary TB compared to those with IgG levels in the lowest tertile (OR: 4.00; 95%CI: 1.13– 14.21; p = 0.03). Our study did not find convincing evidence that SARS-CoV-2 seropositivity was associated with subsequent pulmonary TB disease; however, the association between magnitude of SARS-CoV-2 IgG response and pulmonary TB warrants further investigation. Future prospective studies, evaluating the effects of sex, age and puberty on host immune responses to M. tuberculosis and SARS-CoV-2, will also provide more clarity on the interplay between these two infections. The online version contains supplementary material available at 10.1186/s12879-023-08412-8.
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影响因子：
11.7
作者：
Visca D;Ong CWM;Tiberi S;Centis R;D'Ambrosio L;Chen B;Mueller J;Mueller P;Duarte R;Dalcolmo M;Sotgiu G;Migliori GB;Goletti D
通讯作者：
Goletti D
影响因子：
13.6
作者：
Peluso MJ;Takahashi S;Hakim J;Kelly JD;Torres L;Iyer NS;Turcios K;Janson O;Munter SE;Thanh C;Donatelli J;Nixon CC;Hoh R;Tai V;Fehrman EA;Hernandez Y;Spinelli MA;Gandhi M;Palafox MA;Vallari A;Rodgers MA;Prostko J;Hackett J Jr;Trinh L;Wrin T;Petropoulos CJ;Chiu CY;Norris PJ;DiGermanio C;Stone M;Busch MP;Elledge SK;Zhou XX;Wells JA;Shu A;Kurtz TW;Pak JE;Wu W;Burbelo PD;Cohen JI;Rutishauser RL;Martin JN;Deeks SG;Henrich TJ;Rodriguez-Barraquer I;Greenhouse B
通讯作者：
Greenhouse B
影响因子：
4.6
作者：
Lyadova IV;Panteleev AV
通讯作者：
Panteleev AV
影响因子：
15.9
作者：
Riou, Catherine;du Bruyn, Elsa;Wilkinson, Robert J.
通讯作者：
Wilkinson, Robert J.
DOI：
10.1016/j.ijtb.2020.07.003
发表时间：
2020-12-01
期刊：
The Indian journal of tuberculosis
影响因子：
--
作者：
Udwadia, Zarir F;Vora, Agam;Sara Raju, Reyma
通讯作者：
Sara Raju, Reyma