Bacterial microbiota of the nasal passages across the span of human life.

Bacterial microbiota of the nasal passages across the span of human life.
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DOI:
10.1016/j.mib.2017.10.023
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发表时间:
2018-03
影响因子:
5.4
通讯作者:
Lemon KP
Lemon KP
中科院分区:
生物学2区
文献类型:
--
作者:
Bomar L;Brugger SD;Lemon KP

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人类鼻道是人类主要病原体的宿主。最近的研究表明,鼻道上皮表面的微生物群落是维持健康微环境的关键因素,它既影响对病原体的抵抗力,也影响免疫反应。鼻腔细菌微生物群在人类生命周期中显示出明显的变化,环境因素的破坏可能与短期和长期的健康后果有关,例如对病毒和细菌感染的易感性以及免疫平衡的紊乱。由于婴儿和老年人经历了呼吸道感染的高发病率和死亡率负担,我们回顾了关于健康和这些年龄段的急性呼吸道感染的细菌鼻部微生物区系组成的最新数据。
The human nasal passages host major human pathogens. Recent research suggests that the microbial communities inhabiting the epithelial surfaces of the nasal passages are a key factor in maintaining a healthy microenvironment by affecting both resistance to pathogens and immunological responses. The nasal bacterial microbiota shows distinct changes over the span of human life and disruption by environmental factors might be associated with both short- and long-term health consequences, such as susceptibility to viral and bacterial infections and disturbances of the immunological balance. Because infants and older adults experience a high burden of morbidity and mortality from respiratory tract infections, we review recent data on the bacterial nasal microbiota composition in health and acute respiratory infection in these age groups.
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