Oxytocin enables maternal behaviour by balancing cortical inhibition.
Oxytocin enables maternal behaviour by balancing cortical inhibition.
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DOI：
10.1038/nature14402
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发表时间：
2015-04-23
期刊：
影响因子：
64.8
通讯作者：
Froemke, Robert C.
中科院分区：
文献类型：
--
作者：
Marlin, Bianca J.;Mitre, Mariela;D'amour, James A.;Chao, Moses V.;Froemke, Robert C.
催产素对社会互动和母性行为很重要。然而，关于催产素何时、何地以及如何调节神经回路以改善社会认知，人们知之甚少。在这里，我们展示了催产素如何通过增强听觉皮质幼鼠的叫声反应来增强雌性小鼠的幼崽取回行为。提取行为需要左侧而不是右侧听觉皮质，催产素可加速左侧听觉皮质的提取行为，催产素受体在左侧听觉皮质优先表达。对幼崽叫声的神经反应是偏侧化的，在母体而不是幼崽的左侧皮质中，兴奋和抑制反应是共调的和时间上精确的。最后，将叫声与催产素配对，通过平衡抑制的大小和时间与兴奋来增强反应。我们的结果描述了催产素增加声学社会刺激的突触的基本机制。此外，催产素诱导的可塑性为听觉皮质加工的偏侧化提供了生物学基础。
Oxytocin is important for social interactions and maternal behavior. However, little is known about when, where, and how oxytocin modulates neural circuits to improve social cognition. Here we show how oxytocin enables pup retrieval behavior in female mice by enhancing auditory cortical pup call responses. Retrieval behavior required left but not right auditory cortex, was accelerated by oxytocin in left auditory cortex, and oxytocin receptors were preferentially expressed in left auditory cortex. Neural responses to pup calls were lateralized, with co-tuned and temporally-precise excitatory and inhibitory responses in left cortex of maternal but not pup-naive adults. Finally, pairing calls with oxytocin enhanced responses by balancing the magnitude and timing of inhibition with excitation. Our results describe fundamental synaptic mechanisms by which oxytocin increases the salience of acoustic social stimuli. Furthermore, oxytocin-induced plasticity provides a biological basis for lateralization of auditory cortical processing.
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影响因子：
3.5
作者：
Churchland, Patricia S.;Winkielman, Piotr
通讯作者：
Winkielman, Piotr
影响因子：
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影响因子：
3.3
作者：
Irani, B. G.;Donato, J., Jr.;Olson, D. P.;Lowell, B. B.;Sacktor, T. C.;Reyland, M. E.;Tolson, K. P.;Zinn, A. R.;Ueta, Y.;Sakata, I.;Zigman, J. M.;Elias, C. F.;Clegg, D. J.
通讯作者：
Clegg, D. J.