Exposure to environmental endocrine disruptors and child development.
Exposure to environmental endocrine disruptors and child development.
复制标题
暴露于环境内分泌破坏者和儿童发育。
DOI：
10.1001/archpediatrics.2012.241
复制
发表时间：
2012-06-01
影响因子：
--
通讯作者：
Meeker, John D.
中科院分区：
文献类型：
--
作者：
Meeker, John D.
接触外源性化学物质会通过多种特定的作用方式影响多个部位的内分泌功能，这可能对人类健康和发展产生深远的影响。在美国和世界范围内，人类普遍接触多种已知或可疑的内分泌干扰化学物质 (EDC)，儿童内分泌相关疾病和失调的发病率呈上升趋势。虽然关于接触内分泌干扰物和儿童健康的人类流行病学研究仍然极其有限，但越来越多的证据表明，接触消费品、个人护理产品、食品、饮用水和其他来源中常见的一些化学物质可能会通过改变内分泌功能对儿童发育产生不利影响。这篇叙述性综述简要介绍了几种常见的 EDC（特别关注持久性有机污染物、邻苯二甲酸盐、双酚 A 和当代使用的杀虫剂，它们仅代表所有已知或可疑的 EDC 中的一小部分），概述了 EDC 对儿童发育（胎儿生长、早期生殖道发育、青春期发育、神经发育和肥胖）产生不利影响的人类证据状况，根据现有知识为医疗保健提供者提供指导，并对未来研究提出建议。
Exposure to exogenous chemicals can impact endocrine function at multiple sites and through numerous specific modes of action, which may have far-reaching impacts on human health and development. Widespread human exposure to numerous known or suspected endocrine disrupting chemicals (EDCs) has been documented in the US and worldwide, as have trends for increased rates of endocrine-related diseases and disorders among children. While human epidemiology studies of exposure to EDCs and children’s health remain extremely limited, there is a growing body of evidence showing that exposure to a number of chemicals commonly found in consumer goods, personal care products, food, drinking water, and other sources may adversely impact child development through altered endocrine function. This narrative review provides a brief introduction to several common EDCs (with a specific focus on persistent organic pollutants, phthalates, bisphenol A, and contemporary use pesticides, which only represents a small number of all known or suspected EDCs), an overview of the state of the human evidence for adverse impacts of EDCs on child development (fetal growth, early reproductive tract development, pubertal development, neurodevelopment, and obesity), guidance for health care providers based on current knowledge, and recommendations for future research.
登录
查看更多内容
影响因子：
10.4
作者：
Herbstman JB;Sjödin A;Kurzon M;Lederman SA;Jones RS;Rauh V;Needham LL;Tang D;Niedzwiecki M;Wang RY;Perera F
通讯作者：
Perera F
影响因子：
10.4
作者：
Green R;Hauser R;Calafat AM;Weuve J;Schettler T;Ringer S;Huttner K;Hu H
通讯作者：
Hu H
新生儿重症监护室早产儿接触双酚A和其他酚类物质。
影响因子：
10.4
作者：
Calafat, Antonia M.;Weuve, Jennifer;Ye, Xiaoyun;Jia, Lily T.;Hu, Howard;Ringer, Steven;Huttner, Ken;Hauser, Russ
通讯作者：
Hauser, Russ
影响因子：
8
作者：
Euling, Susan Y.;Herman-Giddens, Marcia E.;Swan, Shanna H.
通讯作者：
Swan, Shanna H.
影响因子：
13.3
作者：
Caserta, D.;Mantovani, A.;Moscarini, M.
通讯作者：
Moscarini, M.