A potential pathogenic association between periodontal disease and Crohn's disease.
A potential pathogenic association between periodontal disease and Crohn's disease.
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DOI：
10.1172/jci.insight.148543
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发表时间：
2021-12-08
期刊：
影响因子：
8
通讯作者：
Kamada N
中科院分区：
文献类型：
--
作者：
Imai J;Ichikawa H;Kitamoto S;Golob JL;Kaneko M;Nagata J;Takahashi M;Gillilland MG 3rd;Tanaka R;Nagao-Kitamoto H;Hayashi A;Sugihara K;Bishu S;Tsuda S;Ito H;Kojima S;Karakida K;Matsushima M;Suzuki T;Hozumi K;Watanabe N;Giannobile WV;Shirai T;Suzuki H;Kamada N
口腔疾病在炎症性肠病（IBD）患者中相对常见。然而，口腔疾病对肠道炎症的贡献仍然未被探索。在这里，我们调查了牙周炎对IBD患者疾病表型的影响。总共招募了60例IBD患者（42例溃疡性结肠炎[UC]和18例克罗恩病[CD]）和45例无IBD的健康对照（HC）进行本临床研究。检查了早期牙周炎对口腔和肠道微生物组以及IBD特征的影响。此外，在入组后对患者进行了长达12个月的前瞻性监测。我们发现，在UC和CD患者中，肠道微生物组与口腔微生物组比HC更相似，这表明IBD患者口腔细菌的异位肠道定植增加。早期牙周炎并没有进一步增强口腔细菌的肠道定植。早期牙周炎的存在并没有显着影响UC和CD患者的临床结果。然而，CD患者的短CD活动指数增加，但在研究期间，没有牙周炎的患者下降或不变的早期牙周炎，CD。因此，在某些CD患者中，早期牙周炎可能与更严重的临床症状相关。
Oral conditions are relatively common in patients with inflammatory bowel disease (IBD). However, the contribution of oral maladies to gut inflammation remains unexplored. Here, we investigated the effect of periodontitis on disease phenotypes of patients with IBD. In all, 60 patients with IBD (42 with ulcerative colitis [UC] and 18 with Crohn’s disease [CD]) and 45 healthy controls (HCs) without IBD were recruited for this clinical investigation. The effects of incipient periodontitis on the oral and gut microbiome as well as IBD characteristics were examined. In addition, patients were prospectively monitored for up to 12 months after enrollment. We found that, in both patients with UC and those with CD, the gut microbiome was significantly more similar to the oral microbiome than in HCs, suggesting that ectopic gut colonization by oral bacteria is increased in patients with IBD. Incipient periodontitis did not further enhance gut colonization by oral bacteria. The presence of incipient periodontitis did not significantly affect the clinical outcomes of patients with UC and CD. However, the short CD activity index increased in patients with CD with incipient periodontitis but declined or was unchanged during the study period in patients without periodontitis. Thus, early periodontitis may associate with worse clinically symptoms in some patients with CD.
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DOI：
10.1126/science.aan4526
发表时间：
2017-10-20
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Atarashi K;Suda W;Luo C;Kawaguchi T;Motoo I;Narushima S;Kiguchi Y;Yasuma K;Watanabe E;Tanoue T;Thaiss CA;Sato M;Toyooka K;Said HS;Yamagami H;Rice SA;Gevers D;Johnson RC;Segre JA;Chen K;Kolls JK;Elinav E;Morita H;Xavier RJ;Hattori M;Honda K
通讯作者：
Honda K
影响因子：
48
作者：
Callahan BJ;McMurdie PJ;Rosen MJ;Han AW;Johnson AJ;Holmes SP
通讯作者：
Holmes SP
DOI：
10.1038/nrgastro.2017.88
发表时间：
2017-10
期刊：
Nature reviews. Gastroenterology & hepatology
影响因子：
--
作者：
Ni J;Wu GD;Albenberg L;Tomov VT
通讯作者：
Tomov VT
影响因子：
30.3
作者：
Gevers D;Kugathasan S;Denson LA;Vázquez-Baeza Y;Van Treuren W;Ren B;Schwager E;Knights D;Song SJ;Yassour M;Morgan XC;Kostic AD;Luo C;González A;McDonald D;Haberman Y;Walters T;Baker S;Rosh J;Stephens M;Heyman M;Markowitz J;Baldassano R;Griffiths A;Sylvester F;Mack D;Kim S;Crandall W;Hyams J;Huttenhower C;Knight R;Xavier RJ
通讯作者：
Xavier RJ
影响因子：
4.5
作者：
Eribe ERK;Olsen I
通讯作者：
Olsen I