Peer victimization predicts heightened inflammatory reactivity to social stress in cognitively vulnerable adolescents.
Peer victimization predicts heightened inflammatory reactivity to social stress in cognitively vulnerable adolescents.
复制标题
同伴受害者预测，认知脆弱的青少年对社会压力的炎症反应增强。
DOI：
10.1111/jcpp.12804
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发表时间：
2018-03
期刊：
影响因子：
--
通讯作者：
Prinstein MJ
中科院分区：
文献类型：
--
作者：
Giletta M;Slavich GM;Rudolph KD;Hastings PD;Nock MK;Prinstein MJ
在青少年时期，同伴伤害是一种强有力的社会压力源，可以给身心健康带来持久的风险。鉴于最近的研究表明炎症会促进各种严重的心理和身体健康问题，这项研究探讨了同伴受害和认知脆弱性（即，消极的认知方式，绝望）在塑造青少年对急性社会压力源的促炎细胞因子反应中发挥作用。有精神病理学风险的青春期女孩（n = 157;法师= 14.73岁; SD = 1.38）暴露于实验室为基础的社会应激源之前和之后，我们评估了唾液中三种关键促炎细胞因子-白细胞介素-6（IL-6）、白细胞介素-1 β（IL-1β）和肿瘤坏死因子-α（TNF-α）的水平。正如假设的那样，具有更大的同伴受害暴露的青少年表现出更大的IL-6和IL-1-β的增加，以应对基于实验室的社会压力。此外，对于所有三种细胞因子单独，以及炎症的组合潜在因素，同伴受害预测增强炎症反应最强烈的青少年与高水平的绝望。研究结果揭示了一个生物学途径，同伴受害可能与认知脆弱性相互作用，影响青少年的健康。
During adolescence, peer victimization is a potent type of social stressor that can confer enduring risk for poor mental and physical health. Given recent research implicating inflammation in promoting a variety of serious mental and physical health problems, this study examined the role that peer victimization and cognitive vulnerability (i.e., negative cognitive styles, hopelessness) play in shaping adolescents’ pro-inflammatory cytokine responses to an acute social stressor. Adolescent girls at risk for psychopathology (n = 157; Mage = 14.73 years; SD = 1.38), were exposed to a laboratory-based social stressor before and after which we assessed salivary levels of three key pro-inflammatory cytokines – interleukin-6 (IL-6), interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α). As hypothesized, adolescents with greater peer victimization exposure exhibited greater increases in IL-6 and IL1-β in response to the laboratory-based social stressor. Moreover, for all three cytokines individually, as well as for a combined latent factor of inflammation, peer victimization predicted enhanced inflammatory responding most strongly for adolescents with high levels of hopelessness. The findings reveal a biological pathway by which peer victimization may interact with cognitive vulnerability to influence health in adolescence.
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影响因子：
2.9
作者：
Keller, Peggy S.;El-Sheikh, Mona;Vaughn, Brian;Granger, Douglas A.
通讯作者：
Granger, Douglas A.
DOI：
10.1038/npp.2010.159
发表时间：
2010-12
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
通讯作者：
--
影响因子：
3.7
作者：
Lopez-Duran, Nestor L.;Kovacs, Maria;George, Charles J.
通讯作者：
George, Charles J.
影响因子：
15.1
作者：
Fagundes, Christopher P.;Glaser, Ronald;Hwang, Beom Seuk;Malarkey, William B.;Kiecolt-Glaser, Janice K.
通讯作者：
Kiecolt-Glaser, Janice K.
影响因子：
15.1
作者：
Mezuk, Briana;Roux, Ana V. Diez;Seeman, Teresa
通讯作者：
Seeman, Teresa