Effect of high- versus low-intensity supervised aerobic and resistance training on modifiable cardiovascular risk factors in type 2 diabetes; the Italian Diabetes and Exercise Study (IDES).
Effect of high- versus low-intensity supervised aerobic and resistance training on modifiable cardiovascular risk factors in type 2 diabetes; the Italian Diabetes and Exercise Study (IDES).
复制标题
DOI：
10.1371/journal.pone.0049297
复制
发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Italian Diabetes Exercise Study (IDES) Investigators
中科院分区：
文献类型：
--
作者：
Balducci S;Zanuso S;Cardelli P;Salvi L;Bazuro A;Pugliese L;Maccora C;Iacobini C;Conti FG;Nicolucci A;Pugliese G;Italian Diabetes Exercise Study (IDES) Investigators
虽然目前关于运动类型和运动量的建议有很强的实验基础，但大规模研究没有明确的证据表明增加训练强度是否为2型糖尿病患者提供额外的益处。比较中等至高强度（HI）与低至中等强度（LI）训练（能量消耗相同，即运动量相同）对可改变的心血管危险因素的影响。意大利糖尿病和运动研究（IDES）的预先指定子分析，这是一项随机多中心前瞻性试验，比较了12个月的监督运动干预与标准护理（2005-2006）。意大利的22家糖尿病门诊诊所。久坐不动的2型糖尿病患者被分配到每周两次监督渐进式有氧和阻力训练加运动咨询（n = 303）。 受试者按中心随机分配至LI（n = 142，136例完成）或HI（n = 161，152例完成）渐进式有氧和阻力训练组，即分别为预测最大耗氧量的55%或70%以及预测1-重复最大值的60%或80%，等体积。 血红蛋白（Hb）A1 c和其他心血管危险因素; 10年冠心病（CHD）风险评分。在LI和HI参与者中，有监督和无监督的体力活动量相似。与LI训练相比，HI训练仅在HbA 1c（平均差异为-0.17%[95%置信区间-0.44，0.10]，P = 0.03）、甘油三酯（-0.12 mmol/l [-0.34，0.10]，P = 0.02）和总胆固醇（-0.24 mmol/l [-0.46，-0.01]，P = 0.04）方面产生了临床边缘性改善，但在其他风险因素和CHD风险评分方面没有改善。 然而，强度不是任何这些参数降低的独立预测因子。HI和LI受试者的不良事件发生率相似。来自大型IDES队列的数据表明，在低健身人群中，如久坐不动的2型糖尿病受试者，增加运动强度是无害的，但不会对心血管风险因素提供额外的益处。 www.ISRCTN.org ISRCTN-04252749。
While current recommendations on exercise type and volume have strong experimental bases, there is no clear evidence from large-sized studies indicating whether increasing training intensity provides additional benefits to subjects with type 2 diabetes. To compare the effects of moderate-to-high intensity (HI) versus low-to-moderate intensity (LI) training of equal energy cost, i.e. exercise volume, on modifiable cardiovascular risk factors. Pre-specified sub-analysis of the Italian Diabetes and Exercise Study (IDES), a randomized multicenter prospective trial comparing a supervised exercise intervention with standard care for 12 months (2005–2006). Twenty-two outpatient diabetes clinics across Italy. Sedentary patients with type 2 diabetes assigned to twice-a-week supervised progressive aerobic and resistance training plus exercise counseling (n = 303). Subjects were randomized by center to LI (n = 142, 136 completed) or HI (n = 161, 152 completed) progressive aerobic and resistance training, i.e. at 55% or 70% of predicted maximal oxygen consumption and at 60% or 80% of predicted 1-Repetition Maximum, respectively, of equal volume. Hemoglobin (Hb) A1c and other cardiovascular risk factors; 10-year coronary heart disease (CHD) risk scores. Volume of physical activity, both supervised and non-supervised, was similar in LI and HI participants. Compared with LI training, HI training produced only clinically marginal, though statistically significant, improvements in HbA1c (mean difference −0.17% [95% confidence interval −0.44,0.10], P = 0.03), triglycerides (−0.12 mmol/l [−0.34,0.10], P = 0.02) and total cholesterol (−0.24 mmol/l [−0.46, −0.01], P = 0.04), but not in other risk factors and CHD risk scores. However, intensity was not an independent predictor of reduction of any of these parameters. Adverse event rate was similar in HI and LI subjects. Data from the large IDES cohort indicate that, in low-fitness individuals such as sedentary subjects with type 2 diabetes, increasing exercise intensity is not harmful, but does not provide additional benefits on cardiovascular risk factors. www.ISRCTN.org ISRCTN-04252749.
登录
查看更多内容
影响因子：
3.3
作者：
DiPietro, L;Dziura, J;Neufer, PD
通讯作者：
Neufer, PD
DOI：
10.1016/0021-9681(86)90195-5
发表时间：
1986-01-01
期刊：
JOURNAL OF CHRONIC DISEASES
影响因子：
--
作者：
FOLSOM, AR;JACOBS, DR;KNUDSEN, J
通讯作者：
KNUDSEN, J
影响因子：
8.2
作者：
Larose, J.;Sigal, R. J.;Kenny, G. P.
通讯作者：
Kenny, G. P.
影响因子：
8.2
作者：
Hansen, D.;Dendale, P.;Jonkers, R. A. M.;Beelen, M.;Manders, R. J. F.;Corluy, L.;Mullens, A.;Berger, J.;Meeusen, R.;van Loon, L. J. C.
通讯作者：
van Loon, L. J. C.
DOI：
10.1016/j.numecd.2007.07.006
发表时间：
2008-11-01
影响因子：
3.9
作者：
Balducci, Stefano;Zanuso, Silvano;Fallucca, Francesco
通讯作者：
Fallucca, Francesco