Gender Difference in Associations Between Telomere Length and Risk Factors in Patients With Stroke.
Gender Difference in Associations Between Telomere Length and Risk Factors in Patients With Stroke.
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中风患者端粒长度与危险因素之间关联的性别差异。
DOI：
10.3389/fnagi.2021.719538
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发表时间：
2021
影响因子：
4.8
通讯作者：
Wu Y
中科院分区：
文献类型：
--
作者：
Wang Y;Jiao F;Zheng H;Kong Q;Li R;Zhang X;Yan L;Hao Y;Wu Y
脑卒中的多种危险因素与端粒长度缩短相关。虽然脑卒中患者的白细胞端粒长度（LTL）较短，但异质性较高。在男性和女性患者中，风险因素可能与LTL差异相关，从而导致异质性。然而，尚未研究中风患者LTL与危险因素之间相关性的性别差异。在这项研究中，我们调查了312例脑卒中患者LTL与危险因素之间的性别差异。采用实时荧光定量PCR方法测定相对LTL值，采用多元线性回归分析方法进行关联分析。我们发现，在调整混杂因素后，所有患者的LTL与甘油三酯（TG）呈负相关[β（95%CI）= −0.69（−1.26，−0.11），P < 0.05]。重要的是，LTL与缺乏锻炼呈负相关[β（95%CI）=-1.80（−3.12，−0.49），P < 0.05]和LDL水平[β（95%CI）= −3.22（−6.05，−0.390），P < 0.05]，而LTL与发育不良呈负相关[β（95%CI）= −2.00（−3.96，−0.07），P < 0.05]和女性患者的糖尿病[β（95%CI）= −2.13（−4.10，−0.27），P < 0.01]。我们的研究表明，在男性和女性脑卒中患者中，LTL与危险因素的相关性不同，提示在将LTL作为脑卒中危险和预后的潜在指标时，应考虑性别差异。我们的研究还提供了一个深入了解，性别差异时，应考虑制定干预策略，预防和治疗中风。
Multiple risk factors of stroke are associated with telomere length shortening. Although leukocyte telomere length (LTL) is shorter in patients with stroke, the heterogeneity is high. Risk factors may be differentially associated with LTL in male and female patients contributing to the heterogeneity. However, the gender difference in associations between LTL and risk factors in stroke patients has not been investigated. In this study, we investigated the gender difference in associations between LTL and risk factors in 312 stroke patients. Real-time quantitative PCR was used to determine relative LTL, and multiple linear regression analysis was applied for association analyses. We found that LTL was negatively associated with triglyceride (TG) in all patients [β(95% CI) = −0.69 (−1.26, −0.11), P < 0.05] after adjusting confounders. Importantly, LTL was negatively associated with lack of exercise [β(95% CI) = −1.80 (−3.12, −0.49), P < 0.05] and LDL levels [β(95% CI) = −3.22 (−6.05, −0.390), P < 0.05] in male patients, while LTL was negatively associated with dyssomnia [β(95%CI) = −2.00 (−3.96, −0.07), P < 0.05] and diabetes [β(95%CI) = −2.13 (−4.10, −0.27), P < 0.01] in female patients. Our study showed that LTL is differently associated with risk factors in male and female patients with stroke, indicating that gender difference should be considered when LTL is potentially applied as an index of risk and prognosis for stroke. Our study also provides an insight into that gender differences should be considered when developing intervention strategies for stroke prevention and treatment.
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影响因子：
3.5
作者：
Huang, Jiaojiao;Peng, Xuemin;Yang, Yan
通讯作者：
Yang, Yan
影响因子：
1.6
作者：
Jin X;Pan B;Dang X;Wu H;Xu D
通讯作者：
Xu D
影响因子：
--
作者：
Luo D;Hou Q;Yu J;Yu D
通讯作者：
Yu D
DOI：
10.1056/nejmra0903373
发表时间：
2009-12-10
期刊：
The New England journal of medicine
影响因子：
--
作者：
Calado RT;Young NS
通讯作者：
Young NS
影响因子：
4.3
作者：
Barcelo, Antonia;Pierola, Javier;Agusti, Alvar
通讯作者：
Agusti, Alvar