Zearalenone Changes the Diversity and Composition of Caecum Microbiota in Weaned Rabbit.
Zearalenone Changes the Diversity and Composition of Caecum Microbiota in Weaned Rabbit.
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玉米赤霉烯酮改变断奶兔盲肠微生物群的多样性和组成
DOI：
10.1155/2018/3623274
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发表时间：
2018
影响因子：
--
通讯作者：
He J
中科院分区：
文献类型：
--
作者：
Li P;Yang S;Zhang X;Huang S;Wang N;Wang M;Long M;He J
霉菌毒素对肠道健康有多种严重影响，但很少有研究评估霉菌毒素对肠道微生物群的影响及其对人类和动物的影响。在这项研究中，我们评估了玉米赤霉烯酮 (ZEA)（最有害的霉菌毒素之一）对兔子盲肠微生物群结构的影响。 28只雄性断奶兔随机分为4组，口服不同浓度的ZEA（400、800和1600μg/kg.b.w）。喂养 28 天后，通过 Illumina Miseq 平台通过 Illumina 测序对兔子盲肠样本中的微生物群落进行 16S rRNA 分析。结果表明，增加ZEA剂量增加了兔子盲肠微生物群的物种丰富度，但没有显着增加物种多样性。此外，不同 ZEA 治疗组样本中的盲肠微生物群根据其给药方案进行了聚类。在门水平上，ZEA 降低了放线菌门的丰度，并显着增加了蓝藻门、协同菌门和变形菌门的丰度。在属水平上，Adlercreutzia、Blautia、Desulfitobacter、Lactobacillus、Oxalobacter 和 p-75-a5 的丰度有所下降。乳杆菌、脱硫杆菌和 p-75-a5 丰度的下降尤其明显。总之，玉米赤霉烯酮可以增加α多样性，但显着降低一些具有重要代谢功能的细菌的丰度。这些发现表明 ZEA 可以改变盲肠微生物群。
Mycotoxins exhibit several severe effects on intestinal health, but few studies have assessed mycotoxins effect on the intestinal microflora and its repercussions to humans and animals. In this study, we evaluated the effect of zearalenone (ZEA), one of the most harmful mycotoxins on the structure of caecal microbiota in rabbits. Twenty-eight male weaned rabbits were randomly divided into four groups and orally given different concentrations of ZEA (400, 800, and 1600 μg/kg.b.w). Microbial communities in caecum samples of rabbits were analyzed for 16S rRNA by Illumina sequencing through Illumina Miseq platform after being fed for 28 days. The results showed that increasing ZEA doses increased the species richness but did not significantly increased the species diversity of the caecum microbiota in the rabbits. In addition, the caecum microbiota from the samples in different ZEA-treated groups was clustered according to their dosing regimens. At the phylum level, ZEA decreased the abundance of Actinobacteria and significantly increased the abundance of Cyanobacteria, Synergistetes, and Proteobacteria. At the genus level, there were declines in the abundance of Adlercreutzia, Blautia, Desulfitobacter, Lactobacillus, Oxalobacter, and p-75-a5. The decrease of abundance in Lactobacillus, Desulfitobacter, and p-75-a5 was particularly noticeable. In conclusion, zearalenone could increase α-diversity but significantly decrease the abundance of some bacteria with the important metabolic functions. These findings suggested that ZEA could modify the caecum microbiota.
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影响因子：
3.4
作者：
Ben Salem, Intidhar;Prola, Alexandre;Abid-Essefi, Salwa
通讯作者：
Abid-Essefi, Salwa
影响因子：
4.4
作者：
El-Nezami, H;Polychronaki, N;Mykkänen, H
通讯作者：
Mykkänen, H
影响因子：
4.1
作者：
Liu, Min;Zhu, Dandan;Chen, Zhihui
通讯作者：
Chen, Zhihui
影响因子：
12.3
作者：
Boulangé CL;Neves AL;Chilloux J;Nicholson JK;Dumas ME
通讯作者：
Dumas ME
影响因子：
3.2
作者：
Galarza-Seeber R;Latorre JD;Bielke LR;Kuttappan VA;Wolfenden AD;Hernandez-Velasco X;Merino-Guzman R;Vicente JL;Donoghue A;Cross D;Hargis BM;Tellez G
通讯作者：
Tellez G