fMRI differences between subjects with low and high responses to alcohol during a stop signal task.
fMRI differences between subjects with low and high responses to alcohol during a stop signal task.
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DOI：
10.1111/j.1530-0277.2011.01590.x
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发表时间：
2012-01
期刊：
影响因子：
--
通讯作者：
Simmons A
中科院分区：
文献类型：
--
作者：
Schuckit MA;Tapert S;Matthews SC;Paulus MP;Tolentino NJ;Smith TL;Trim RS;Hall S;Simmons A
对酒精的低水平反应（即低LR）是一种受基因影响的表型，预示着以后的酒精中毒。虽然低LR至少在一定程度上反映了大脑对酒精的低反应，但低LR的生理基础直到最近才得到解决。49对饮酒但未饮酒的18-25岁配对的受试者（N = 98, 53%为女性）分别在不同的酒精挑战中建立了低和高LRs，在两个事件相关的功能磁共振成像（fMRI）会话（安慰剂和~ 0.7 ml/kg酒精）中进行评估，同时执行已验证的停止信号任务。在饮酒期间，高LR组和低LR组的血液酒精含量相同。尽管LR组在任务上的表现相似，但在错误加工和抑制性加工过程中，高LR组与低LR组和LR组的血氧水平依赖（BOLD）信号均存在显著的条件效应。在大多数具有显著（校正p< 0.05，簇>1344 μl） LR组×酒精/安慰剂条件相互作用的簇中，低LR组在酒精后表现出相对较少的激活，而高LR组在酒精后表现出更多的错误和抑制相关激活。这是首次功能性磁共振成像（fMRI）研究显示，未来罹患威胁生命疾病风险不同的健康人群之间存在显著差异。研究结果可能表明，大脑机制有助于低LR如何增加未来大量饮酒和酒精依赖的风险。
A low level of response (i.e., a low LR) to alcohol is a genetically influenced phenotype that predicts later alcoholism. While the low LR reflects, at least in part, a low brain response to alcohol, the physiological underpinnings of the low LR have only recently been addressed. Forty-nine drinking but not yet alcoholic matched pairs of 18-25-year-old subjects (N = 98; 53% female) with low and high LRs as established in separate alcohol challenges were evaluated in two event-related functional magnetic resonance imaging (fMRI) sessions (placebo and ~ 0.7 ml/kg of alcohol) while performing a validated stop signal task. The high and low LR groups had identical blood alcohol levels during the alcohol session. Significant high versus low LR group and LR group × condition effects were observed in blood oxygen level dependent (BOLD) signal during error and inhibitory processing, despite similar LR-group performance on the task. In most clusters with significant (corrected p<.05, clusters >1344 μl) LR group × alcohol/placebo condition interactions, the low LR group demonstrated relatively less, whereas the high LR group demonstrated more, error and inhibition-related activation after alcohol compared to placebo. This is one of the first fMRI studies to demonstrate significant differences between healthy groups with different risks for a future life threatening disorder. The results may suggest a brain mechanism that contributes to how a low LR might enhance the risk for future heavy drinking and alcohol dependence.
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影响因子：
2.3
作者：
Matthews, Scott;Simmons, Alan;Paulus, Martin
通讯作者：
Paulus, Martin
DOI：
10.15288/jsa.2004.65.16
发表时间：
2004-01-01
期刊：
JOURNAL OF STUDIES ON ALCOHOL
影响因子：
--
作者：
Chiu, TM;Mendelson, JH;Mello, NK
通讯作者：
Mello, NK
DOI：
10.1111/j.1530-0277.1997.tb03860.x
发表时间：
1997-08-01
影响因子：
3.2
作者：
Breslin, FC;Kapur, BM;Cappell, H
通讯作者：
Cappell, H
DOI：
10.1111/j.1530-0277.2010.01152.x
发表时间：
2010-05-01
影响因子：
3.2
作者：
Joslyn, Geoff;Ravindranathan, Ajay;White, Raymond L.
通讯作者：
White, Raymond L.
DOI：
10.15288/jsa.2002.63.237
发表时间：
2002-03-01
期刊：
JOURNAL OF STUDIES ON ALCOHOL
影响因子：
--
作者：
Fillmore, MT;Blackburn, J
通讯作者：
Blackburn, J