Type 2-diabetes is associated with elevated levels of TNF-alpha, IL-6 and adiponectin and low levels of leptin in a population of Mexican Americans: a cross-sectional study.
Type 2-diabetes is associated with elevated levels of TNF-alpha, IL-6 and adiponectin and low levels of leptin in a population of Mexican Americans: a cross-sectional study.
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DOI：
10.1016/j.cyto.2011.09.029
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发表时间：
2012-01
期刊：
影响因子：
3.8
通讯作者：
Fisher-Hoch, Susan P.
中科院分区：
文献类型：
--
作者：
Mirza, S.;Hossain, Monir;Mathews, Christine;Martinez, Perla;Pino, Paula;Gay, Jennifer L.;Rentfro, Anne;McCormick, Joseph B.;Fisher-Hoch, Susan P.
该研究的目的是确定临床诊断的糖尿病患者中糖尿病和炎症之间的关联。我们假设糖尿病的低度炎症与血糖控制水平有关。采用横断面设计，我们比较了促炎和抗炎细胞因子在社区招募的队列367墨西哥裔美国人与2型糖尿病具有广泛的血糖水平。采用多重ELISA法检测细胞因子（IL-6、TNF-α、IL-1β、IL-8）和脂肪因子（脂联素、瘦素和β-内酰胺酶）。我们的数据表明，糖尿病总体上与IL-6、瘦素、CRP和TNF-α水平升高密切相关，而血糖控制恶化与IL-6、瘦素水平升高呈正线性相关。即使在控制BMI和年龄后，相关性仍然具有统计学意义（p = 0.01）。然而，当基于血糖控制进行比较时，TNF-α之间的相关性减弱。观察到年龄和BMI与糖尿病之间对IL-8、CRP和CRP的强烈交互作用。墨西哥裔美国人糖尿病患者的细胞因子/脂肪因子谱表明低度炎症与血糖控制质量之间存在关联。在我们的人群中独特的是，慢性炎症伴随着较低的瘦素水平。
The goal of the study was to determine the association between diabetes and inflammation in clinically diagnosed diabetes patients. We hypothesized that low-grade inflammation in diabetes is associated with the level of glucose control. Using a cross-sectional design we compared pro and anti-inflammatory cytokines in a community recruited cohort of 367 Mexican Americans with type 2-diabetes having a wide range blood glucose levels. Cytokines (IL-6, TNF-α, IL-1β, IL-8) and adipokines (adiponectin, resistin and leptin) were measured using multiplex ELISA. Our data indicated that diabetes as whole was strongly associated with elevated levels of IL-6, leptin, CRP and TNF-α, whereas worsening of glucose control was positively and linearly associated with high levels of IL-6, leptin. The associations remained statistically significant even after controlling for BMI and age (p = 0.01). The association between TNF-α, however, was attenuated when comparisons were performed based on glucose control. Strong interaction effects between age and BMI and diabetes were observed for IL-8, resistin, and CRP. The cytokine/adipokine profiles of Mexican Americans with diabetes suggest an association between low-grade inflammation and quality of glucose control. Unique to in our population is that the chronic inflammation is accompanied by lower levels of leptin.
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影响因子：
7.7
作者：
Duncan, BB;Schmidt, MI;Heiss, G
通讯作者：
Heiss, G
影响因子：
2.1
作者：
King GA;Deemer SE;Thompson DL
通讯作者：
Thompson DL
影响因子：
7.7
作者：
Duncan, BB;Schmidt, MI;Heiss, G
通讯作者：
Heiss, G
影响因子：
3.1
作者：
Dennis RJ;Maldonado D;Rojas MX;Aschner P;Rondón M;Charry L;Casas A
通讯作者：
Casas A
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影响因子：
56.9
作者：
HOTAMISLIGIL, GS;SHARGILL, NS;SPIEGELMAN, BM
通讯作者：
SPIEGELMAN, BM