Reducing Phthalate, Paraben, and Phenol Exposure from Personal Care Products in Adolescent Girls: Findings from the HERMOSA Intervention Study.
Reducing Phthalate, Paraben, and Phenol Exposure from Personal Care Products in Adolescent Girls: Findings from the HERMOSA Intervention Study.
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DOI：
10.1289/ehp.1510514
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发表时间：
2016-10
影响因子：
10.4
通讯作者：
Parra KL
中科院分区：
文献类型：
--
作者：
Harley KG;Kogut K;Madrigal DS;Cardenas M;Vera IA;Meza-Alfaro G;She J;Gavin Q;Zahedi R;Bradman A;Eskenazi B;Parra KL
个人护理产品是青春期女孩接触邻苯二甲酸酯、对羟基苯甲酸酯、三氯生和二苯甲酮-3（BP-3）等可能干扰内分泌的化学品的来源。我们招募了100名拉丁裔女孩参加一项以青年为主导的、以社区为基础的参与性研究干预研究，以确定使用标签上注明不含这些化学物质的个人护理产品3天是否可以降低尿液浓度。使用高效液相色谱/串联质谱法分析干预前后尿液样本中的邻苯二甲酸酯代谢物、对羟基苯甲酸酯、三氯生和BP-3。在为期3天的干预中，尿中邻苯二甲酸单乙酯（MEP）浓度平均下降了27.4%（95% CI：-39.3，-13.2）;尿中邻苯二甲酸单正丁酯（MnBP）和邻苯二甲酸单异丁酯（MiBP）浓度未观察到显著变化。尼泊金甲酯和尼泊金丙酯浓度分别降低43.9%（95% CI：-61.3，-18.8）和45.4%（95% CI：-63.7，-17.9）。出乎意料的是，对羟基苯甲酸乙酯和对羟基苯甲酸丁酯的浓度增加，尽管总体浓度较低，并且在几乎一半的样品中未检测到。三氯生浓度降低35.7%（95% CI：-53.3，-11.6），BP-3浓度降低36.0%（95% CI：-51.0，-16.4）。这项研究表明，消费者可用的技术，如选择标记为不含邻苯二甲酸酯，对羟基苯甲酸酯，三氯生和BP-3的个人护理产品，可以减少个人暴露于可能的内分泌干扰化学品。让青年参与研究的设计和实施是招募、保留、遵守和接受干预措施的关键。哈雷KG，Kogut K，Madrigal DS，Cardenas M，Vera IA，Meza-Alfaro G，She J，Gavin Q，Zahedi R，Bradman A，Eskenazi B，Parra KL. 2016.减少青春期女孩从个人护理产品中接触邻苯二甲酸酯、对羟基苯甲酸酯和苯酚：来自HERMOSA干预研究的结果。环境健康展望124：1600-1607; http：dx.doi.org/10.1289/ehp.1510514
Personal care products are a source of exposure to potentially endocrine-disrupting chemicals such as phthalates, parabens, triclosan, and benzophenone-3 (BP-3) for adolescent girls. We enrolled 100 Latina girls in a youth-led, community-based participatory research intervention study to determine whether using personal care products whose labels stated they did not contain these chemicals for 3 days could lower urinary concentrations. Pre- and postintervention urine samples were analyzed for phthalate metabolites, parabens, triclosan, and BP-3 using high-performance liquid chromatography/tandem mass spectrometry. Urinary concentrations of mono-ethyl phthalate (MEP) decreased by 27.4% (95% CI: –39.3, –13.2) on average over the 3-day intervention; no significant changes were seen in urinary concentrations of mono-n-butyl phthalate (MnBP) and mono-isobutyl phthalate (MiBP). Methyl and propyl paraben concentrations decreased by 43.9% (95% CI: –61.3, –18.8) and 45.4% (95% CI: –63.7, –17.9), respectively. Unexpectedly, concentrations of ethyl and butyl paraben concentrations increased, although concentrations were low overall and not detected in almost half the samples. Triclosan concentrations decreased by 35.7% (95% CI: –53.3, –11.6), and BP-3 concentrations decreased by 36.0% (95% CI: –51.0, –16.4). This study demonstrates that techniques available to consumers, such as choosing personal care products that are labeled to be free of phthalates, parabens, triclosan, and BP-3, can reduce personal exposure to possible endocrine-disrupting chemicals. Involving youth in the design and implementation of the study was key to recruitment, retention, compliance, and acceptability of the intervention. Harley KG, Kogut K, Madrigal DS, Cardenas M, Vera IA, Meza-Alfaro G, She J, Gavin Q, Zahedi R, Bradman A, Eskenazi B, Parra KL. 2016. Reducing phthalate, paraben, and phenol exposure from personal care products in adolescent girls: findings from the HERMOSA Intervention Study. Environ Health Perspect 124:1600–1607; http://dx.doi.org/10.1289/ehp.1510514
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