Taurine supplementation prevents ethanol-induced decrease in serum adiponectin and reduces hepatic steatosis in rats.
Taurine supplementation prevents ethanol-induced decrease in serum adiponectin and reduces hepatic steatosis in rats.
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DOI：
10.1002/hep.22811
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发表时间：
2009-05
期刊：
影响因子：
13.5
通讯作者：
Nagy, Laura E.
中科院分区：
文献类型：
--
作者：
Chen, Xiaocong;Sebastian, Becky M.;Tang, Hui;McMullen, Megan M.;Axhemi, Armend;Jacobsen, Donald W.;Nagy, Laura E.
慢性乙醇喂养降低脂肪细胞脂联素和循环脂联素的表达。脂联素治疗慢性乙醇喂养预防小鼠肝损伤。慢性乙醇喂养也增加了脂肪组织中的氧化和内质网（ER）应激。在这里，我们测试的假设，补充牛磺酸，作为一种化学伴侣/渗透压和增强细胞抗氧化活性的氨基酸的功能，将防止乙醇诱导的脂联素表达减少，减轻肝损伤。血清脂联素浓度下降，早在4-7天后喂养大鼠36%的乙醇饮食。这种快速下降与皮下脂肪组织中的氧化应激增加有关，但与ER应激无关。牛磺酸可预防乙醇诱导的氧化应激，并增加脂肪组织中炎性细胞因子的表达。乙醇喂养也迅速降低了皮下脂肪组织中调节脂联素表达的转录因子（C/EBPα，PPARγ和PPARα）的表达。牛磺酸阻止了乙醇诱导的C/EBPα和PPARα的降低，使脂联素mRNA和血清脂联素浓度正常化。在肝脏中，牛磺酸至少部分通过增加参与脂肪酸氧化的基因表达来预防乙醇诱导的氧化应激并减弱TNF-α表达和脂肪变性。在皮下脂肪组织中，牛磺酸降低乙醇诱导的氧化应激和细胞因子的表达，以及脂联素mRNA的正常表达。牛磺酸可防止乙醇诱导的血清脂联素降低;脂联素正常化与肝脏氧化应激、TNF-α表达和脂肪变性减少相关。总之，这些数据表明，牛磺酸对乙醇诱导的脂肪和肝脏组织损伤具有重要的保护作用。
Chronic ethanol feeding decreases expression of adiponectin by adipocytes and circulating adiponectin. Adiponectin treatment during chronic ethanol feeding prevents liver injury in mice. Chronic ethanol feeding also increases oxidative and endoplasmic reticulum (ER) stress in adipose tissue. Here we tested the hypothesis that supplemental taurine, an amino acid that functions as a chemical chaperone/osmolyte and enhances cellular anti-oxidant activity, would prevent ethanol-induced decreases in adiponectin expression and attenuate liver injury. Serum adiponectin concentrations decreased as early as 4–7 days after feeding rats a 36% ethanol diet. This rapid decrease was associated with increased oxidative, but not ER, stress in subcutaneous adipose tissue. Taurine prevented ethanol-induced oxidative stress and increased inflammatory cytokine expression in adipose tissue. Ethanol feeding also rapidly decreased expression of transcription factors regulating adiponectin expression (C/EBPα, PPARγ and PPARα) in subcutaneous adipose tissue. Taurine prevented the ethanol-induced decrease in C/EBPα and PPARα normalizing adiponectin mRNA and serum adiponectin concentrations. In the liver, taurine prevented ethanol-induced oxidative stress and attenuated TNF-α expression and steatosis, at least in part, by increasing expression of genes involved in fatty acid oxidation. In subcutaneous adipose tissue, taurine decreased ethanol-induced oxidative stress and cytokine expression, as well as normalized expression of adiponectin mRNA. Taurine prevented ethanol-induced decreases in serum adiponectin; normalized adiponectin was associated with a reduction in hepatic oxidative stress, TNF-α expression and steatosis. Taken together, these data demonstrate that taurine has important protective effects against ethanol-induced tissue injury in both adipose and liver.
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影响因子：
3.5
作者：
Militante, JD;Lombardini, JB
通讯作者：
Lombardini, JB
影响因子：
7.7
作者：
Iwaki, M;Matsuda, M;Shimomura, I
通讯作者：
Shimomura, I
影响因子：
3.5
作者：
Hamilton, E. J.;Berg, H. M.;Bakker, A. J.
通讯作者：
Bakker, A. J.
影响因子：
8.7
作者：
Hotta, K;Funahashi, T;Matsuzawa, Y
通讯作者：
Matsuzawa, Y
DOI：
10.1152/ajpendo.00387.2006
发表时间：
2007-02-01
影响因子：
5.1
作者：
Chen, Xiaocong;Sebastian, Becky M.;Nagy, Laura E.
通讯作者：
Nagy, Laura E.