Mating alters gene expression patterns in Drosophila melanogaster male heads.
Mating alters gene expression patterns in Drosophila melanogaster male heads.
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DOI：
10.1186/1471-2164-11-558
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发表时间：
2010-10-11
期刊：
影响因子：
4.4
通讯作者：
Carney GE
中科院分区：
文献类型：
--
作者：
Ellis LL;Carney GE
行为是一个复杂的过程，是遗传和环境信息整合的结果。黑腹果蝇依靠多种感觉方式来繁殖成功，交配会引起两性的生理变化，影响生殖输出或行为。其中一些效应可能是由基因表达的变化介导的。求偶和交配会改变雌性的转录谱，但交配如何影响雄性的基因表达尚不清楚。我们使用果蝇基因组阵列，以确定发生在交配的男性头部基因表达谱的变化。交配后2小时，交配和对照头之间有47个基因不同。许多交配反应基因在非神经头部组织中高度表达，包括称为脂肪体的脂肪组织。一个脂肪体富集基因，女性特有的独立于Transformer（适合），是体细胞性别决定层次的下游目标，调节果蝇生殖行为以及一些脂肪表达基因的表达的遗传途径;其他三个交配反应位点也是该途径的下游组件。另一种在脂肪中表达的交配反应基因，保幼激素酯酶（Jhe），是强壮的雄性求偶行为和交配成功所必需的。我们的研究表明，交配导致男性头部基因表达谱的变化，并支持越来越多的工作涉及脂肪信号在行为调节。由于几个交配诱导基因是性别决定层次的靶基因，额外的交配反应位点也可能是这一途径的下游成分。
Behavior is a complex process resulting from the integration of genetic and environmental information. Drosophila melanogaster rely on multiple sensory modalities for reproductive success, and mating causes physiological changes in both sexes that affect reproductive output or behavior. Some of these effects are likely mediated by changes in gene expression. Courtship and mating alter female transcript profiles, but it is not known how mating affects male gene expression. We used Drosophila genome arrays to identify changes in gene expression profiles that occur in mated male heads. Forty-seven genes differed between mated and control heads 2 hrs post mating. Many mating-responsive genes are highly expressed in non-neural head tissues, including an adipose tissue called the fat body. One fat body-enriched gene, female-specific independent of transformer (fit), is a downstream target of the somatic sex-determination hierarchy, a genetic pathway that regulates Drosophila reproductive behaviors as well as expression of some fat-expressed genes; three other mating-responsive loci are also downstream components of this pathway. Another mating-responsive gene expressed in fat, Juvenile hormone esterase (Jhe), is necessary for robust male courtship behavior and mating success. Our study demonstrates that mating causes changes in male head gene expression profiles and supports an increasing body of work implicating adipose signaling in behavior modulation. Since several mating-induced genes are sex-determination hierarchy target genes, additional mating-responsive loci may be downstream components of this pathway as well.
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影响因子：
10.5
作者：
Dauwalder, B;Tsujimoto, S;Mattox, W
通讯作者：
Mattox, W
影响因子：
3.3
作者：
Anseloni, VCZ;He, F;Lidow, MS
通讯作者：
Lidow, MS
DOI：
10.1016/j.cub.2009.06.063
发表时间：
2009-09-15
期刊：
Current biology : CB
影响因子：
--
作者：
Dalton JE;Lebo MS;Sanders LE;Sun F;Arbeitman MN
通讯作者：
Arbeitman MN
影响因子：
30.8
作者：
Anholt, RRH;Dilda, CL;Mackay, TFC
通讯作者：
Mackay, TFC
影响因子：
2.4
作者：
Cann, MJ;Chung, E;Levin, LR
通讯作者：
Levin, LR