Amygdala central nucleus modulation of cerebellar learning with a visual conditioned stimulus.
Amygdala central nucleus modulation of cerebellar learning with a visual conditioned stimulus.
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DOI：
10.1016/j.nlm.2018.03.011
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发表时间：
2018-04
影响因子：
2.7
通讯作者：
Freeman JH
中科院分区：
文献类型：
--
作者：
Farley SJ;Albazboz H;De Corte BJ;Radley JJ;Freeman JH
以往的研究发现，中央杏仁核(CEA)的可逆性失活严重损害了听觉条件刺激(CS)对小脑依赖性眨眼条件反射(EBC)的习得和保持。CEA和脑桥基底核(BPN)之间的单突触通路可能有助于小脑学习。然而，由于CEA投射到内侧听觉丘脑(EBC中听觉CS通路的关键部分)，CEA对小脑学习的影响可能是听觉刺激所特有的。在这里，我们使用视觉CS研究了CEA促进大鼠EBC获得和保留的一般性。正如我们以前使用听觉CS进行的研究一样，用蝇草酚灭活CEA会严重损害视觉CS的EBC的获得和保留。将训练延长到15个100次的试验阶段导致了EBC的获得，表明CEA在小脑学习中起着调制作用，而不是EBC必要的神经回路的一部分。追踪实验证实，来自CEA的轴突到达BPN和内侧听觉丘脑(必要的听觉CS通路的一部分)，但在腹侧膝状体(必要的视觉CS通路的一部分)中没有发现。神经解剖学结果表明，CEA很可能通过其向BPN的投射来调节小脑学习。本研究结果与CEA通过BPN增加CS相关感觉传入小脑皮质和间位核从而调节小脑学习的假说相一致。这种与CS相关的输入的增加被认为是在EBC期间增加了对CS的关注。
Previous studies found that reversible inactivation of the central amygdala (CeA) severely impairs acquisition and retention of cerebellum-dependent eye-blink conditioning (EBC) with an auditory conditioned stimulus (CS). A monosynaptic pathway between the CeA and basilar pontine nuclei (BPN) may be capable of facilitating cerebellar learning. However, given that the CeA projects to the medial auditory thalamus, a critical part of the auditory CS pathway in EBC, the CeA influence on cerebellar learning could be specific to auditory stimuli. Here we examined the generality of CeA facilitation of EBC acquisition and retention in rats using a visual CS. As in our previous studies using an auditory CS, inactivation of the CeA with muscimol severely impaired acquisition and retention of EBC with a visual CS. Extending training to 15 100-trial sessions resulted in acquisition of EBC, indicating that the CeA plays a modulatory role in cerebellar learning and is not part of the necessary neural circuitry for EBC. Tract-tracing experiments verified that axons from the CeA reach both the BPN and medial auditory thalamus (part of the necessary auditory CS pathway), but were not found in the ventral lateral geniculate (part of the necessary visual CS pathway). The neuroanatomical results suggest that the CeA most likely modulates cerebellar learning through its projection to the BPN. The findings of the current study are consistent with the hypothesis that the CeA modulates cerebellar learning by increasing CS-related sensory input to the cerebellar cortex and interpositus nucleus via the BPN. This increase in CS-related input is thought to constitute an increase in attention to the CS during EBC.
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影响因子：
3.4
作者：
Siegel JJ;Taylor W;Gray R;Kalmbach B;Zemelman BV;Desai NS;Johnston D;Chitwood RA
通讯作者：
Chitwood RA
影响因子：
1.9
作者：
HOLLAND, PC;GALLAGHER, M
通讯作者：
GALLAGHER, M
影响因子：
1.9
作者：
ROSEN, JB;HITCHCOCK, JM;DAVIS, M
通讯作者：
DAVIS, M
影响因子：
2
作者：
Halverson, Hunter E.;Freeman, John H.
通讯作者：
Freeman, John H.
DOI：
10.1101/lm.1002508
发表时间：
2008-07
期刊：
Learning & memory (Cold Spring Harbor, N.Y.)
影响因子：
--
作者：
Halverson HE;Poremba A;Freeman JH
通讯作者：
Freeman JH