Membrane lipid unsaturation as physiological adaptation to animal longevity.
Membrane lipid unsaturation as physiological adaptation to animal longevity.
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DOI：
10.3389/fphys.2013.00372
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发表时间：
2013-12-17
影响因子：
4
通讯作者：
Pamplona R
中科院分区：
文献类型：
--
作者：
Naudí A;Jové M;Ayala V;Portero-Otín M;Barja G;Pamplona R
氧气在地球大气中的出现代表了对祖先生物体的重要选择压力，并有助于建立结构和功能系统进化变化的速度。利用氧气进行高效能源生产的进化是复杂生物进化的驱动力。然而，与其使用相关的氧化还原反应负责产生活性物质（来自氧气和脂质），由于基本细胞成分的氧化化学修饰而产生破坏性影响。因此，有氧生活需要抗氧化防御系统的出现和选择。因此，在分子和结构的抗氧化剂防御进化的高度多样性。在下面的段落中，我们分析了生物膜的适应作为一种动态的结构防御反应物种进化的动物。特别是，我们的目标是描述的生理机制的基础上的结构适应细胞膜氧化应激和解释这种适应机制的意义，并审查有关膜组成和动物物种的寿命之间的联系的艺术状态。
The appearance of oxygen in the terrestrial atmosphere represented an important selective pressure for ancestral living organisms and contributed toward setting up the pace of evolutionary changes in structural and functional systems. The evolution of using oxygen for efficient energy production served as a driving force for the evolution of complex organisms. The redox reactions associated with its use were, however, responsible for the production of reactive species (derived from oxygen and lipids) with damaging effects due to oxidative chemical modifications of essential cellular components. Consequently, aerobic life required the emergence and selection of antioxidant defense systems. As a result, a high diversity in molecular and structural antioxidant defenses evolved. In the following paragraphs, we analyze the adaptation of biological membranes as a dynamic structural defense against reactive species evolved by animals. In particular, our goal is to describe the physiological mechanisms underlying the structural adaptation of cellular membranes to oxidative stress and to explain the meaning of this adaptive mechanism, and to review the state of the art about the link between membrane composition and longevity of animal species.
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DOI：
10.1093/gerona/62.4.352
发表时间：
2007-04-01
影响因子：
5.1
作者：
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通讯作者：
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影响因子：
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影响因子：
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作者：
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