Electrical field distribution of Change-N1 and its prepulse inhibition
Electrical field distribution of Change-N1 and its prepulse inhibition
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Change-N1的电场分布及其前脉冲抑制
DOI：
10.1016/j.neulet.2021.135804
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发表时间：
2021
期刊：
影响因子：
2.5
通讯作者：
Inui K.
中科院分区：
文献类型：
--
作者：
Watanabe T;Motomura E;Kawano Y;Fujii S;Hakumoto Y;Morimoto M;Nakatani K;Okada M;Inui K.
连续声音中声音特征（测试）的突然变化会引发听觉诱发电位，峰值约为。变化开始后 100–180ms (Change-N1)。 Change-N1 会被先前的微弱变化刺激（前脉冲）减弱，这种现象称为前脉冲抑制（PPI）。在这项脑电图研究中，我们比较了头皮电极中的这两个指标。 Change-N1 是通过重复 100Hz 的 70dB 咔嗒声时声压突然增加 10dB 引起的，并在 31 名健康受试者中使用 22 个电极进行记录。预脉冲是在测试开始前 30、40 和 50ms 的连续三次点击中减少 10dB。通过耳机以均匀的概率随机呈现四种刺激（单独测试、预脉冲测试、单独预脉冲和单独背景）。结果表明：（1）再次确认额叶/中央中线电极适合记录Change-N1； (2) Change-N1显示右半球优势； (3) 区域（前额叶/额叶/中央）和半球（中线/左/右）之间的％PPI没有差异； (4)前额电极处的Change-N1振幅及其PPI与额叶电极处呈正相关。这些结果支持使用 Change-N1 及其 PPI 作为评估个体变化检测灵敏度和抑制功能的工具。使用前额电极可以作为筛查测试的一种选择。
An abrupt change in a sound feature (Test) in a continuous sound elicits an auditory evoked potential, peaking at approx. 100–180 ms (Change-N1) after the change onset. Change-N1 is attenuated by a preceding weak change stimulus (Prepulse), in the phenomenon known as prepulse inhibition (PPI). In this electroencephalographic study, we compared these two indexes among scalp electrodes. Change-N1 was elicited by an abrupt 10-dB increase in sound pressure in repeats of a 70-dB click sound at 100 Hz and was recorded using 22 electrodes in 31 healthy subjects. The prepulse was a 10-dB decrease in three consecutive clicks at 30, 40, and 50 ms before the Test onset. Four stimuli (Test alone, Test with Prepulse, Prepulse alone, and background alone) were presented randomly through headphones at an even probability. The results demonstrated that: (1) Electrodes at the frontal/central midline were reconfirmed to be suitable to record Change-N1; (2) Change-N1 showed right-hemisphere predominance; (3) There was no difference in the %PPI among regions (prefrontal/frontal/central) and hemispheres (midline/left/right); and (4) the Change-N1 amplitude and its PPI at prefrontal electrodes were positively correlated with those at the frontal electrodes. These results support the use of Change-N1 and its PPI as a tool to evaluate the change detection sensitivity and inhibitory function in individuals. The use of prefrontal electrodes can be an option for a screening test.
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