An emerging recombinant cluster of nephropathogenic strains of avian infectious bronchitis virus in Korea.
An emerging recombinant cluster of nephropathogenic strains of avian infectious bronchitis virus in Korea.
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DOI：
10.1016/j.meegid.2011.01.007
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发表时间：
2011-04
期刊：
影响因子：
--
通讯作者：
Song CS
中科院分区：
文献类型：
--
作者：
Lim TH;Lee HJ;Lee DH;Lee YN;Park JK;Youn HN;Kim MS;Lee JB;Park SY;Choi IS;Song CS
传染性支气管炎病毒（IBV）通过其基因组的点突变和重组不断进化，随后IBV变种的出现使疾病控制变得复杂。本研究的目的是调查从 2005 年至 2010 年期间收集的韩国商业鸡群中分离出的新 IBV 变种的遗传特征。系统发育分析显示，所有新 IBV 分离株均属于韩国 II 组 (K-II)，其中包括致病性 IBV 菌株。然而，这些分离株形成了一个新的基因簇，与两个不同的 K-II 亚群（KM91 样和 QX 样）区分开来。在 S1 基因中鉴定出重组事件，其假定的亲本菌株是 KM91 样或 QX 样亚群。此外，在IBV分离株的S1基因中观察到两个交叉位点。这些结果表明，不同遗传组的异源毒株之间已经发生了自然遗传重组，并可能导致新IBV毒株的出现。这一发现提供了有关IBV演变的重要信息，对于韩国有效控制IB至关重要。
The infectious bronchitis virus (IBV) is continuously evolving through point mutation and recombination of their genome, subsequently the emergence of IBV variants complicates disease control. The objective of this study was to investigate genetic characterization of new IBV variants isolated from commercial chicken flocks in Korea collected between 2005 and 2010. Phylogenetic analysis revealed that all new IBV isolates belonged to Korean group II (K-II), which included the nephropathogenic IBV strains. However, the isolates formed a new gene cluster that was distinguished from the two distinct K-II subgroups (KM91-like and QX-like). Recombination events were identified in the S1 gene, with their putative parental strains being the KM91-like or QX-like subgroup. In addition, two crossover sites were observed in the S1 gene of IBV isolates. These results suggest that natural genetic recombination between heterologous strains classified into different genetic groups has occurred and may have caused the emergence of new IBV strains. This finding provides important information on IBV evolution and is essential for the effective control of IB in Korea.
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DOI：
10.1016/j.tvjl.2007.08.018
发表时间：
2009-01
期刊：
Veterinary journal (London, England : 1997)
影响因子：
--
作者：
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通讯作者：
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影响因子：
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影响因子：
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作者：
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