Association between diabetes mellitus and risk of Parkinson's disease: A prisma-compliant meta-analysis.
Association between diabetes mellitus and risk of Parkinson's disease: A prisma-compliant meta-analysis.
复制标题
糖尿病与帕金森氏病风险之间的关联：符合Prisma的荟萃分析。
DOI：
10.1002/brb3.2082
复制
发表时间：
2021-08
影响因子：
3.1
通讯作者：
Tang J
中科院分区：
文献类型：
--
作者：
Liu W;Tang J
先前的研究表明，糖尿病（DM）与帕金森病（PD）风险之间的关系不一致。该研究旨在进行荟萃分析，以阐明糖尿病是否是帕金森病的危险因素。我们在PubMed、Web of Science、MEDLINE、EMBASE和谷歌Scholar等数据库中检索了2020年7月之前发表的关于糖尿病对PD风险影响的文章，检索词为：（“diabetes”OR“diabetes”）和（“Parkinson’s disease”OR“PD”）。我们使用STATA 12.0软件计算DM和PD风险之间的多变量比值比（OR）或相对风险（RR）和95%置信区间（CI）。本研究最终纳入7项病例对照研究（包括26,654例PD患者）和9项队列研究（包括3,819,006例DM患者），探讨DM与PD风险的关系。meta分析显示DM与PD风险升高相关（OR/RR = 1.15, 95% CI 1.03-1.28, i2 = 92.4%, p < 0.001）。亚组研究显示，在队列研究中，糖尿病与PD的高风险相关（RR = 1.29, 95% CI 1.15-1.45, i2 = 93.9%, p < 0.001），而在病例对照研究中，糖尿病与PD的风险无显著相关性（OR = 0.74, 95% CI 0.51-1.09, i2 = 82.3%, p < 0.001）。敏感性分析显示，当任何一项研究被排除在所有meta分析之外时，影响的方向没有变化。此外，Begg检验、Egger检验和漏斗图均未显示显著的发表偏倚风险。总之，我们试图确定是否既往的糖尿病发病可能会增加发展为帕金森病的风险。需要进行越来越多的大规模前瞻性研究来评估糖尿病和帕金森病之间的关系。我们试图确定是否既往发病的糖尿病可能会增加发展为帕金森病的风险。需要进行越来越多的大规模前瞻性研究来评估糖尿病和帕金森病之间的关系。
Previous studies showed inconsistent results regarding associations between diabetes mellitus (DM) and risk of Parkinson's disease (PD). The study aimed to make a meta‐analysis to clarify whether DM is a risk factor for PD. We searched for articles regarding the effect of DM on risk of PD and published before July 2020 with search terms as follows: (“diabetes mellitus” OR “diabetes”) AND (“Parkinson's disease” OR “PD”) in the following databases: PubMed, Web of Science, MEDLINE, EMBASE, and Google Scholar. We used STATA 12.0 software to compute multivariate odds ratio (OR) or relative risk (RR) and 95% confidence intervals (CI) regarding the association between DM and risk of PD. The present study finally included 7 case–control studies (including 26,654 PD patients) and 9 cohort studies (including 3,819,006 DM patients) exploring the association between DM and risk of PD. The meta‐analysis indicated that DM was related to elevated risk of PD (OR/RR = 1.15, 95% CI 1.03–1.28, I 2 = 92.4%, p < .001). Subgroup study showed that DM was associated with higher risk of PD in cohort studies (RR = 1.29, 95% CI 1.15–1.45, I 2 = 93.9%, p < .001), whereas no significant association was indicated between DM and risk of PD in case–control studies (OR = 0.74, 95% CI 0.51–1.09, I 2 = 82.3%, p < .001). Sensitivity analysis showed no changes in the direction of effect when any one study was excluded from all meta‐analyses. In addition, Begg's test, Egger's test, and funnel plot showed no significant risks of publication bias. In conclusion, we have tried to determine whether prior onset of DM may contribute to the risk of developing PD. More and more large‐scale prospective studies should be conducted to evaluate the relationship between DM and PD. We have tried to determine whether prior onset of DM may contribute to the risk of developing PD. More and more large‐scale prospective studies should be conducted to evaluate the relationship between DM and PD.
登录
查看更多内容
影响因子：
16.2
作者：
Hu, Gang;Jousilahti, Pekka;Tuomilehto, Jaakko
通讯作者：
Tuomilehto, Jaakko
影响因子：
4.1
作者：
D'Amelio, Marco;Ragonese, Paolo;Savettieri, Giovanni
通讯作者：
Savettieri, Giovanni
影响因子：
9.9
作者：
De Pablo-Fernandez, Eduardo;Goldacre, Raph;Warner, Thomas T.
通讯作者：
Warner, Thomas T.
影响因子：
168.9
作者：
Kalia, Lorraine V.;Lang, Anthony E.
通讯作者：
Lang, Anthony E.
影响因子：
4.4
作者：
Miyake, Yoshihiro;Tanaka, Keiko;Nagai, Masaki
通讯作者：
Nagai, Masaki