Gestational ethanol exposure alters the behavioral response to ethanol odor and the expression of neurotransmission genes in the olfactory bulb of adolescent rats.
Gestational ethanol exposure alters the behavioral response to ethanol odor and the expression of neurotransmission genes in the olfactory bulb of adolescent rats.
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DOI：
10.1016/j.brainres.2008.11.023
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发表时间：
2009-02-03
期刊：
影响因子：
2.9
通讯作者：
Youngentob SL
中科院分区：
文献类型：
--
作者：
Middleton FA;Carrierfenster K;Mooney SM;Youngentob SL
胎儿暴露于乙醇是高度预测的倾向，摄入乙醇在青春期和子宫内的化学感觉可塑性已被牵连作为一个促成因素，在这个过程中。最近的啮齿动物研究表明，胎儿乙醇暴露的结果在一个调谐的无条件的嗅和神经生理嗅觉反应，乙醇气味的婴儿动物。重要的是，在这个年龄段增加的乙醇亲和力的一个显着比例可以归因于调谐的行为反应乙醇气味。这些影响在成年人中是不存在的。使用行为的方法和全面的基因表达谱筛选强大的转录差异诱导嗅球，我们研究了是否乙醇暴露通过母亲的饮食结果在改变响应乙醇气味，持续到青春期后期，如果是这样，可能与这种影响的分子机制。与对照组相比，胎儿暴露改变：青少年嗅乙醇气味的反应与先前观察到的变化一致的婴儿动物;和参与突触传递和可塑性以及神经元发育（细胞命运和轴突/神经突生长）的基因的表达。这些数据提供了证据的持久性嗅觉介导的反应，乙醇进入青春期。此外，他们提供了一个重要的关系，胎儿暴露于乙醇，青少年气味反应的药物和潜在的潜在分子机制的气味引导的行为反应。
Fetal exposure to ethanol is highly predictive of the propensity to ingest ethanol during adolescence and in utero chemosensory plasticity has been implicated as a contributing factor in this process. Recent rodent studies have shown that fetal ethanol exposure results in a tuned unconditioned sniffing and neurophysiological olfactory response to ethanol odor in infant animals. Importantly, a significant proportion of increased ethanol avidity at this age can be attributed to the tuned behavioral response to ethanol odor. These effects are absent in adults. Using behavioral methods and comprehensive gene expression profiling to screen for robust transcriptional differences induced in the olfactory bulb, we examined whether ethanol exposure via maternal diet results in an altered responsiveness to ethanol odor that persists into late adolescence and, if so, the molecular mechanisms that may be associated with such effects. Compared to controls, fetal exposure altered: the adolescent sniffing response to ethanol odor consistent with the previously observed changes in infant animals; and the expression of genes involved in synaptic transmission and plasticity as well as neuronal development (both cell fate and axon/neurite outgrowth). These data provide evidence for a persistence of olfactory-mediated responsiveness to ethanol into the period of adolescence. Further, they provide insight into an important relationship between fetal exposure to ethanol, adolescent odor responsiveness to the drug and potential underlying molecular mechanisms for the odor-guided behavioral response.
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影响因子：
2.9
作者：
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