Olfactory dysfunction is associated with neuropsychiatric manifestations in Parkinson's disease.
Olfactory dysfunction is associated with neuropsychiatric manifestations in Parkinson's disease.
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DOI：
10.1002/mds.23792
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发表时间：
2011-09
影响因子：
8.6
通讯作者：
Duda, John E.
中科院分区：
文献类型：
--
作者：
Morley, James F.;Weintraub, Daniel;Mamikonyan, Eugenia;Moberg, Paul J.;Siderowf, Andrew D.;Duda, John E.
嗅觉减退、精神障碍和认知问题是帕金森病常见的非运动表现，但它们之间的关系尚不清楚。为了调查嗅觉功能障碍和神经精神症状之间的关系，我们对来自学术医疗中心的两个运动障碍诊所的248名患者进行了一项横断面研究。精神方面的测量包括老年抑郁量表-15、抑郁症状量表、状态焦虑量表、冷漠量表和帕金森精神病评定量表。认知测量采用简易精神状态检查、霍普金斯言语学习测验修订版、数字广度、伦敦塔-德雷克塞尔测验和Stroop颜色词测验。嗅觉用宾夕法尼亚大学的嗅觉鉴定测试进行测试。嗅觉和情绪测量之间没有显著相关性，但嗅觉评分低于中位数的患者中精神病性症状更常见（30%对12%，p<0.001）。嗅觉越差，记忆力越差（霍普金斯言语学习测试-修订版延迟回忆项目：平均值（标准差）6.2（3.2）vs. 8.4（2.8），p<0.001）和执行能力（伦敦塔总移动次数，52（38）vs. 34（21），p<0.001）。在逻辑回归模型中，在调整了年龄、性别和疾病特征后，气味识别分数是这些认知测试异常表现的一个重要预测因素。嗅觉减退、精神病和特定认知障碍之间的关系可能反映了Lewy病理的解剖分布，并表明嗅觉功能障碍可能是其他神经系统疾病的生物标志物。未来的前瞻性研究是必要的，以评估是否嗅觉减退，帕金森病的一个非常早期的特点，可能被用来预测其他常见的非运动症状的出现。
Hyposmia, psychiatric disorders and cognitive problems are common non-motor manifestations in Parkinson's Disease but how they are related remains unclear. To investigate the relationship between olfactory dysfunction and neuropsychiatric manifestations we performed a cross-sectional study of 248 patients at two movement disorders clinics at academic medical centers. Psychiatric measures were the Geriatric Depression Scale-15, Inventory of Depressive Symptomatology, State Anxiety Inventory, Apathy Scale and Parkinson's Psychosis Rating Scale. Cognitive measures were the Mini Mental State Examination, Hopkins Verbal Learning Test-Revised, Digit Span, Tower of London-Drexel and the Stroop Color Word Test. Olfaction was tested with the University of Pennsylvania Smell Identification test. There was no significant association between olfaction and mood measures, but psychotic symptoms were more common in patients with olfaction scores below the median (30% vs. 12%, p<0.001). Worse olfaction was associated with poorer memory (Hopkins Verbal Learning Test-Revised delayed recall items: mean(standard deviation) 6.2(3.2) vs. 8.4(2.8), p<0.001) and executive performance (Tower of London total moves, 52(38) vs. 34(21), p<0.001). Odor-identification score was a significant predictor of abnormal performance on these cognitive tests after adjustment for age, sex and disease characteristics in logistic regression models. The relationship between hyposmia, psychosis, and specific cognitive impairments may reflect the anatomic distribution of Lewy pathology and suggests that olfactory dysfunction could be a biomarker of additional extranigral disease. Future prospective studies are warranted to assess whether hyposmia, a very early feature of Parkinson's disease, might be used to predict the appearance of other common non-motor symptoms.
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DOI：
10.1093/brain/awq079
发表时间：
2010-06
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Bohnen NI;Müller ML;Kotagal V;Koeppe RA;Kilbourn MA;Albin RL;Frey KA
通讯作者：
Frey KA
影响因子：
8.6
作者：
Aarsland, Dag;Marsh, Laura;Schrag, Anette
通讯作者：
Schrag, Anette
影响因子：
8.6
作者：
Boesveldt, Sanne;Verbaan, Dagmar;Berendse, Henk W.
通讯作者：
Berendse, Henk W.
影响因子：
8.6
作者：
Barone, Paolo;Antonini, Angelo;Del Dotto, Paolo
通讯作者：
Del Dotto, Paolo
影响因子：
2.9
作者：
DOTY, RL;SHAMAN, P;DANN, M
通讯作者：
DANN, M