The role of systemic dehydration in vocal fold healing: Preliminary findings.
The role of systemic dehydration in vocal fold healing: Preliminary findings.
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DOI：
10.1002/lio2.942
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发表时间：
2022-12
影响因子：
1.9
通讯作者：
Sivasankar, M. Preeti
中科院分区：
文献类型：
--
作者：
Venkatraman, Anumitha;Hawkins, Jan;McCain, Robyn;Duan, Chenwei;do Nascimento, Naila Cannes;Cox, Abigail;Sivasankar, M. Preeti
系统性脱水会负面改变声带炎症和细胞连接标志物的表达。这些生物学变化可能对受伤声带的愈合过程产生下游影响。在真皮层，水化减少会导致炎症并延迟愈合。尚不清楚是否在声带组织中观察到这种生物效应。在啮齿动物模型中研究急性双侧声带损伤后全身性脱水对声带愈合结局的影响。18只全身脱水和18只水合正常的成年雄性Sprague道利大鼠出现双侧声带损伤或无损伤（N = 9/组）。损伤后24小时测量炎症介质和上皮细胞连接标记物的声带基因表达水平。促炎基因标志物（IL-1β; TNF-α）在伴有声带损伤的系统性脱水与无损伤相比的反应中差异表达。上皮细胞连接标志物（钙粘蛋白-3、桥粒芯糖蛋白-1）在全身性脱水后也表现出不同的趋势，但这些数据无统计学显著性。全身性脱水可能会影响细胞声带愈合过程在24小时内。这些发现为进一步研究水合状态如何影响声带组织恢复和影响临床护理奠定了基础。充足的水分对于发声和声带损伤的恢复至关重要。本研究调查是否全身性脱水不利影响声带伤口愈合过程。
Systemic dehydration negatively alters the expression of vocal fold inflammatory and cell junction markers. These biological changes can have downstream effects on the healing processes of injured vocal folds. In the dermis, reduced hydration prolongs inflammation and delays healing. It is unknown whether this biological effect is observed in vocal fold tissue. To investigate the effects of systemic dehydration on vocal fold healing outcomes following acute, bilateral vocal fold injury in a rodent model. Eighteen systemic dehydrated and 18 euhydrated adult male Sprague Dawley rats experienced bilateral vocal fold injuries or no injury (N = 9/group). Vocal fold gene expression levels of inflammatory mediators and epithelial cell junction markers were measured 24 h post‐injury. Pro‐inflammatory gene markers (IL‐1β; TNF‐α) were differentially expressed in response to systemic dehydration with vocal fold injury compared to non‐injury. Epithelial cell junction markers (Cadherin‐3, Desmoglein‐1) also exhibited divergent trends following systemic dehydration, but these data were not statistically significant. Systemic dehydration may affect cellular vocal fold healing processes within 24 h. These findings lay the groundwork for further investigation of how hydration status can affect vocal fold tissue recovery and influence clinical care. Adequate hydration is essential for voice production and recovery from vocal fold injury. This study investigates whether systemic dehydration adversely affects vocal fold wound healing processes.
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DOI：
10.1002/lary.28881
发表时间：
2021-04
期刊：
The Laryngoscope
影响因子：
--
作者：
Duan C;do Nascimento NC;Calve S;Cox A;Sivasankar MP
通讯作者：
Sivasankar MP
影响因子：
2.6
作者：
Leydon, Ciara;Imaizumi, Mitsuyoshi;Fried, Marvin P.
通讯作者：
Fried, Marvin P.
影响因子：
2.9
作者：
Ling, Changying;Yamashita, Masaru;Welham, Nathan V.
通讯作者：
Welham, Nathan V.
影响因子：
4.3
作者：
Chang Z;Kishimoto Y;Hasan A;Welham NV
通讯作者：
Welham NV
影响因子：
2.2
作者：
Cox, Abigail;do Nascimento, Naila Cannes;Sivasankar, M. Preeti
通讯作者：
Sivasankar, M. Preeti