Relationships of GDF8 and 11 and Their Antagonists With Decline of Grip Strength Among Older Adults in the Baltimore Longitudinal Study of Aging.
Relationships of GDF8 and 11 and Their Antagonists With Decline of Grip Strength Among Older Adults in the Baltimore Longitudinal Study of Aging.
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巴尔的摩老龄纵向研究中 GDF8 和 11 及其拮抗剂与老年人握力下降的关系。
DOI：
10.1093/gerona/glad135
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Semba,RichardD
中科院分区：
文献类型：
--
作者：
Yamaguchi,Yuko;Zhu,Min;Moaddel,Ruin;Palchamy,Elango;Ferrucci,Luigi;Semba,RichardD
尽管生长/分化因子11 （GDF11）、生长/分化因子8 （GDF8）及其循环拮抗剂，包括GDF11和GDF8前肽、卵泡listatin （FST）、WAP、卵泡listatin/Kazal、免疫球蛋白、Kunitz和Netrin Domain Containing (WFIKKN)1和WFIKKN2，已被证明能影响小鼠骨骼肌和衰老，但这些循环因子与人类表型的关系尚不清楚。本研究旨在描述534名≥65岁的成年人血浆GDF8、GDF11、FST、WFIKKN1和WFIKKN2浓度与握力下降之间的关系，这些成年人参加了巴尔的摩老龄化纵向研究，并随时间测量了握力。采用反应监测-串联质谱法测定血浆GDF8和GDF11成熟蛋白、GDF8和GDF11前肽、FST（异构体FST315和裂解形式FST303）、WFIKKN1和WFIKKN2浓度。在基线和随访时测量握力（中位随访8.87年）。男性和女性握力的平均（标准差）分别下降了- 0.84（2.45）和- 0.60 (1.32)kg/年。在校正潜在混杂因素的多变量线性回归分析中，血浆GDF8和GDF11成熟蛋白、GDF8和GDF11前肽、FST315、FST303、WFIKKN1和WFIKKN2浓度不能独立预测男性或女性握力下降。总之，循环中的GDF8、GDF11及其拮抗剂似乎不会影响老年男性或女性握力的下降。
Although growth/differentiation factor 11 (GDF11), growth/differentiation factor 8 (GDF8), and their circulating antagonists, which include GDF11 and GDF8 propeptides, follistatin (FST), WAP, Follistatin/Kazal, Immunoglobulin, Kunitz And Netrin Domain Containing (WFIKKN)1, and WFIKKN2, have been shown to influence skeletal muscle and aging in mice, the relationship of these circulating factors with human phenotypes is less clear. This study aimed to characterize the relationship between plasma GDF8, GDF11, FST, WFIKKN1, and WFIKKN2 concentrations with the decline of grip strength in 534 adults, ≥65 years, who participated in the Baltimore Longitudinal Study of Aging and had grip strength measured over time. Plasma GDF8 and GDF11 mature proteins, GDF8 and GDF11 propeptides, FST (isoform FST315 and cleaved form FST303), WFIKKN1, and WFIKKN2 concentrations were measured using selected reaction monitoring–tandem mass spectrometry at baseline. Grip strength was measured at baseline and at follow-up visits (median follow-up 8.87 years). Mean (standard deviation) grip strength declined in men and women by −0.84 (2.45) and −0.60 (1.32) kg/year, respectively. Plasma GDF8 and GDF11 mature proteins, GDF8 and GDF11 propeptides, FST315, FST303, WFIKKN1, and WFIKKN2 concentrations were not independently predictive of the decline of grip strength in men or women in multivariable linear regression analyses that adjusted for potential confounders. In conclusion, circulating GDF8, GDF11, and their antagonists do not appear to influence the decline of grip strength in older men or women.
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