Hemato-vascular origins of endothelial progenitor cells?

Hemato-vascular origins of endothelial progenitor cells?
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DOI:
10.1016/j.mvr.2010.02.003
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发表时间:
2010-05
影响因子:
3.1
通讯作者:
Hirschi KK
Hirschi KK
中科院分区:
医学3区
文献类型:
--
作者:
Chao H;Hirschi KK

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许多研究表明,在各种组织和器官中存在前体细胞,其具有分化为内皮细胞和壁细胞的潜力,并且在不同的生理和病理情况下有助于血管形成。虽然仍然缺乏共识,在该领域的起源,表型和功能特征的推定血管祖细胞群体,都同意,需要进一步的研究,以充分探索和利用其巨大的潜力,作为血管疾病的细胞治疗,作为调制器的出生后血管形成,并作为疾病的生物标志物。在此,我们将审查内皮祖细胞/前体细胞类型的表型和功能特征,认为是来自造血和血管系统,有助于出生后血管形成,并讨论其潜在的谱系关系。
Numerous studies have suggested the presence of precursor cells in various tissues and organs with potential to differentiate into endothelial and mural cells, and contribute to blood vessel formation in different physiological and pathological circumstances. Although there is still a lack of consensus in the field regarding the origin, and phenotypic and functional characteristics of putative vascular progenitor cell populations, all agree that further studies are needed to fully explore and exploit their great potential as cell therapy for vascular diseases, as modulators of postnatal blood vessel formation, and as disease biomarkers. Herein, we will review the phenotypic and functional characteristics of endothelial progenitor/precursor cell types thought to be derived from the hematopoietic and vascular systems and contribute to postnatal blood vessel formation, and discuss their potential lineage relationships.
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