Changes in Neuronal Activity in the Anterior Cingulate Cortex and Primary Somatosensory Cortex With Nonlinear Burst and Tonic Spinal Cord Stimulation.
Changes in Neuronal Activity in the Anterior Cingulate Cortex and Primary Somatosensory Cortex With Nonlinear Burst and Tonic Spinal Cord Stimulation.
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DOI：
10.1111/ner.13116
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发表时间：
2020-07
期刊：
影响因子：
--
通讯作者：
Winkelstein BA
中科院分区：
文献类型：
--
作者：
Quindlen-Hotek JC;Kent AR;De Anda P;Kartha S;Benison AM;Winkelstein BA
尽管非线性爆发和强直性 SCS 被认为可以通过不同的疼痛途径治疗神经性疼痛，但这些方式对体内大脑活动的有效性尚未得到研究。本研究比较了疼痛性神经根病大鼠模型中非线性爆发和强直 SCS 后大脑中的神经元放电模式。在疼痛性颈神经根压迫 (NRC) 或假手术后第 7 天，在非线性爆发或强直 SCS 之前和之后记录 ACC 或 S1 中的神经元活动。将非线性突发 SCS 的幅度设置为 60% 和 90% 运动阈值，以研究较低幅度 SCS 对大脑活动的影响。在轻刷和爪子的有害捏捏期间和之后立即记录神经元活动。神经元放电的变化被测量为 SCS 后峰值相对于 SCS 前基线的百分比变化。与 NRC 后的强直 (p < 0.05) 相比，以及与假手术后的 90% 非线性爆发 (p < 0.04) 和 SCS 前基线 (p < 0.03) 相比，60% 非线性爆发后刷牙期间 ACC 活性降低。与 NRC 的强直相比，在 60% 和 90% 非线性爆发后的捏压过程中，ACC 神经元活性降低 (p < 0.01)。与基线相比，两组捏捏期间 ACC 发射均减少了 60%（p < 0.02）。在 NRC S1 神经元中，强直 SCS 在光刷期间从基线放电减少 (p < 0.01)；在刷牙和捏捏过程中，从基线开始的发射次数减少了 60% (p < 0.01)。非线性突发 SCS 减少了 ACC 因疼痛刺激而产生的放电；较低幅度的非线性突发似乎具有最大的影响。强直和非线性突发 SCS 在 S1 中可能具有类似的效果。
Although nonlinear burst and tonic SCS are believed to treat neuropathic pain via distinct pain pathways, the effectiveness of these modalities on brain activity in vivo has not been investigated. This study compared neuronal firing patterns in the brain after nonlinear burst and tonic SCS in a rat model of painful radiculopathy. Neuronal activity was recorded in the ACC or S1 before and after nonlinear burst or tonic SCS on day 7 following painful cervical nerve root compression (NRC) or sham surgery. The amplitude of nonlinear burst SCS was set at 60% and 90% motor threshold to investigate the effect of lower amplitude SCS on brain activity. Neuronal activity was recorded during and immediately following light brush and noxious pinch of the paw. Change in neuron firing was measured as the percent change in spikes post-SCS relative to pre-SCS baseline. ACC activity decreases during brush after 60% nonlinear burst compared to tonic (p < 0.05) after NRC and compared to 90% nonlinear burst (p < 0.04) and pre-SCS baseline (p < 0.03) after sham. ACC neuron activity decreases (p < 0.01) during pinch after 60% and 90% nonlinear burst compared to tonic for NRC. The 60% of nonlinear burst decreases (p < 0.02) ACC firing during pinch in both groups compared to baseline. In NRC S1 neurons, tonic SCS decreases (p < 0.01) firing from baseline during light brush; 60% nonlinear burst decreases (p < 0.01) firing from baseline during brush and pinch. Nonlinear burst SCS reduces firing in the ACC from a painful stimulus; a lower amplitude nonlinear burst appears to have the greatest effect. Tonic and nonlinear burst SCS may have comparable effects in S1.
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影响因子：
--
作者：
Ekstrom A
通讯作者：
Ekstrom A
影响因子：
3.1
作者：
De Ridder, Dirk;Vanneste, Sven;Vancamp, Tim
通讯作者：
Vancamp, Tim
影响因子：
2.8
作者：
Crosby, Nathan D.;Keiser, Melanie D. Goodman;Winkelstein, Beth A.
通讯作者：
Winkelstein, Beth A.
DOI：
10.1073/pnas.96.14.7705
发表时间：
1999-07-06
影响因子：
11.1
作者：
Bushnell, MC;Duncan, GH;Carrier, B
通讯作者：
Carrier, B
影响因子：
4.1
作者：
Cameron, T
通讯作者：
Cameron, T