Expression of chemokine receptor CXCR7 in colorectal carcinoma and its prognostic significance.
Expression of chemokine receptor CXCR7 in colorectal carcinoma and its prognostic significance.
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趋化因子受体CXCR7在结直肠癌中的表达及其预后意义
DOI：
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发表时间：
2015-10
期刊：
影响因子：
--
通讯作者：
Chu Xiaoyuan
中科院分区：
文献类型：
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作者：
Mao Xiaobei;Wang Rui;Chen Longbang;Chu Xiaoyuan
先前的研究表明趋化因子受体CXCR7在肿瘤发生发展中发挥着关键作用。然而，CXCR7 在结直肠癌 (CRC) 中的临床病理学和预后意义尚未完全了解。本研究的目的是探讨CXCR7在结直肠癌中的表达及其临床意义。首先，进行定量RT-PCR和Western blot检测，测定20对CRC组织和相应的癌旁非肿瘤组织中CXCR7 mRNA和蛋白的表达。接下来采用免疫组织化学方法检测另外96例CRC组织中CXCR7蛋白的表达情况，并分析其与患者临床病理因素的相关性。最后，通过Kaplan-Meier法和Cox比例风险模型对CXCR7与5年总生存（OS）和无进展生存（PFS）的相关性进行统计分析。结果显示，CRC组织中CXCR7 mRNA和蛋白的表达水平显着高于正常组织。 CXCR7 阳性表达与淋巴结转移（P < 0.001）、远处转移（P = 0.017）和晚期 TNM 分期（P < 0.001）显着相关。 CXCR7 阳性表达的患者被证明与较差的 OS 和 PFS 相关（分别为 P < 0.001、P < 0.001）。此外，多变量生存分析显示CXCR7表达水平可能是CRC患者OS和PFS的独立预测因素。总的来说，CRC 中 CXCR7 的阳性表达与肿瘤发展和患者不良预后相关。
Previous studies have shown that chemokine receptor CXCR7 plays critical roles in tumor development. However, the clinicopathological and prognostic significance of CXCR7 in colorectal carcinoma (CRC) has not been fully understood. The aim of our study is to investigate the expression of CXCR7 and its clinical significance in CRC. First, quantitative RT-PCR and Western blot assays were performed to determine the expression of CXCR7 mRNA and protein in 20 paired of CRC tissues and corresponding adjacent non-tumor tissues. Next, immunohistochemistry was performed to detect the expression of CXCR7 protein in another 96 cases of CRC tissues, and analyze its correlation with clinicopathological factors of patients. Finally, the correlation of CXCR7 with 5-year overall survival (OS) and progression free survival (PFS) was statistically analyzed by the Kaplan-Meier method and Cox proportional hazards model. Results showed that the expression levels of CXCR7 mRNA and protein were significantly higher in CRC tissues than in normal tissues. Positive CXCR7 expression was observed to be significantly correlated with lymph nodal metastasis (P < 0.001), distant metastasis (P = 0.017), and advanced TNM stage (P < 0.001). Patients with positive expression of CXCR7 were demonstrated to be associated with worse OS and PFS (P < 0.001, P < 0.001, respectively). Moreover, multivariate survival analysis revealed that CXCR7 expression level might be an independent predictive factor for OS and PFS of CRC patients. Collectively, positive CXCR7 expression in CRC was correlated with tumor development and poor prognosis of patients.
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影响因子：
3.8
作者：
Esencay M;Sarfraz Y;Zagzag D
通讯作者：
Zagzag D
CXCR4 的过表达与顺铂化疗耐药显着相关，可能是上皮性卵巢癌的预后因素
影响因子：
3.8
作者：
Li J;Jiang K;Qiu X;Li M;Hao Q;Wei L;Zhang W;Chen B;Xin X
通讯作者：
Xin X
影响因子：
9.1
作者：
V. Tripathi;R. Verma;A. Dinda;N. Malhotra;J. Kaur;K. Luthra
通讯作者：
V. Tripathi;R. Verma;A. Dinda;N. Malhotra;J. Kaur;K. Luthra
影响因子：
9.2
作者：
Sun, Xueqing;Cheng, Guangcun;Hao, Mingang;Zheng, Jianghua;Zhou, Xiaoming;Zhang, Jian;Taichman, Russell S.;Pienta, Kenneth J.;Wang, Jianhua
通讯作者：
Wang, Jianhua
影响因子：
8.8
作者：
Guillemot, E.;Karimdjee-Soilihi, B.;Pradelli, E.;Benchetrit, M.;Goguet-Surmenian, E.;Millet, M-A;Larbret, F.;Michiels, J-F;Birnbaum, D.;Alemanno, P.;Schmid-Antomarchi, H.;Schmid-Alliana, A.
通讯作者：
Schmid-Alliana, A.