Retinofugal projections in the mouse.
Retinofugal projections in the mouse.
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DOI：
10.1002/cne.23635
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发表时间：
2014-11-01
影响因子：
2.5
通讯作者：
Studholme, Keith M.
中科院分区：
文献类型：
--
作者：
Morin, Lawrence P.;Studholme, Keith M.
实验室小鼠越来越成为视觉系统研究的对象，但尚未对该物种的视觉投射进行全面评价。在这里，眼内注射霍乱毒素B亚单位后，投影被可视化和绘制。使用标准程序处理组织，应用于30am自由浮动切片，二氨基联苯胺作为显色剂。老鼠的视网膜投射到大约46个大脑区域，包括14个以前没有在这个物种中描述过的区域。这些包括两个杏仁核、对角带水平肢、室旁下丘脑核、几个视丘脑核、神经旁核、几个顶前核和下丘背侧皮层。在同侧上丘中间层的狭窄部分也观察到致密的视网膜斑块。支配内侧末梢核的副视束上束也被确定为贯穿其长度的终末区。结果与先前描述的小鼠内在感光视网膜神经节细胞的投影，以及仓鼠，尼罗河草鼠和实验室大鼠的数据进行了比较。尽管在细节上有很多不同，但这四种动物的视网膜投影模式是相似的。大多数视网膜接收区域的具体视觉功能是未知的，但有大量的视网膜投射到嗅觉和听觉有关的区域。
The laboratory mouse is increasingly a subject for visual system investigation, but there has been no comprehensive evaluation of this species’ visual projections. Here, projections were visualized and mapped following intraocular injection of cholera toxin B subunit. Tissue was processed using standard procedures applied to 30 Am free floating sections with diaminobenzidine as the chromogen. The mouse retina projects to approximately 46 brain regions, including 14 not previously described in this species. These include two amygdaloid nuclei, the horizontal limb of the diagonal band, the paraventricular hypothalamic nucleus, several visual thalamic nuclei, the paranigral nucleus, several pretectal nuclei, and the dorsal cortex of the inferior colliculus. Dense retinal patches were also observed in a narrow portion of the ipsilateral intermediate layer of the superior colliculus. The superior fasciculus of the accessory optic tract, which innervates the medial terminal nucleus, was also determined to be a terminal zone throughout its length. The results are compared with previous descriptions of projections from mouse intrinsically photoreceptive retinal ganglion cells, and with data from the hamster, Nile grass rat and laboratory rat. The retinal projection patterns are similar in all four species, although there are many differences with respect to the details. The specific visual functions of most retinorecipient areas are unknown, but there is substantial convergence of retinal projections onto regions concerned with olfaction and audition.
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影响因子：
3.6
作者：
CLANCY, AN;GOLDMAN, BD;MACRIDES, F
通讯作者：
MACRIDES, F
影响因子：
64.8
作者：
Gueler, Ali D.;Ecker, Jennifer L.;Hattar, Samer
通讯作者：
Hattar, Samer
影响因子：
3.7
作者：
COOPER, HM;PARVOPASSU, F;MAGNIN, M
通讯作者：
MAGNIN, M
影响因子：
5.7
作者：
Dhande OS;Huberman AD
通讯作者：
Huberman AD
影响因子：
13.9
作者：
Krauzlis RJ;Lovejoy LP;Zénon A
通讯作者：
Zénon A