Nonlinear pharmacokinetics of ethanol elimination in long sleep and short sleep mice.
Nonlinear pharmacokinetics of ethanol elimination in long sleep and short sleep mice.
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长睡眠和短睡眠小鼠乙醇消除的非线性药代动力学。
DOI：
10.1111/j.1530-0277.1983.tb05420.x
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Collins,AC
中科院分区：
文献类型：
--
作者：
Gilliam,DM;Bloedow,DC;Collins,AC
人类和狗体内乙醇消除的药代动力学研究表明，通过应用 MichaelikMenten 酶动力学可以最好地描述血液中的乙醇消除。为了将 Michaelis-Menten 模型的应用扩展到小鼠的乙醇消除中，我们使用从长睡眠 (Ls) 和短睡眠 (SS) 选定的小鼠品系中获得的连续血液样本，在推注、静脉注射乙醇后测量了消除率。对 Widmark 线性模型和非线性 Michaelis-Menten 模型预测的消除率进行了比较。还确定了每个小鼠系的分布体积。这些小鼠中的乙醇消除符合非线性模型。 SS 小鼠获得的 Vmax 和 Km 值显着高于 LS；然而，品系之间的线性消除率没有发现显着差异。 LS 小鼠表现出比 SS 小鼠显着更大的分布体积。 Michaelis-Menten 模型预测，当血液乙醇浓度大于 120 mg% 时，SS 乙醇代谢应大于 LS 代谢。结果支持这样的建议：乙醇的消除可以通过米氏动力学来最好地描述。乙醇消除的品系差异可能是由于用于选择这些小鼠的剂量的变化和/或特定乙醇代谢系统的诱导造成的。
Pharmacokinetic studies of ethanol elimination in humans and dogs have suggested that elimination from the blood can be best described through the application of MichaelikMenten enzyme kinetics. In an attempt to extend the application of the Michaelis‐Menten model to ethanol elimination in mice, we measured elimination rates using serial blood samples obtained from the long sleep (Ls) and short sleep (SS) selected mouse lines following a bolus, intravenous ethanol infusion. A comparison was made between elimination rates as predicted by Widmark's linear model and by the nonlinear Michaelis‐Menten model. Volume of distribution was also determined for each mouse line.Ethanol elimination in these mice conformed to the nonlinear model. Significantly greater Vmaxand Kmvalues were obtained for the SS mice than for the LS; however, no significant difference in linear elimination rates was found between lines. The LS mice exhibited a significantly greater volume of distribution than did the SS. The Michaelis‐Menten model predicts that SS ethanol metabolism should be greater than LS metabolism at blood ethanol concentrations greater than 120 mg%. The results support the suggestion that ethanol elimination can be best described by Michaelis‐Menten kinetics. Line differences in ethanol elimination may have resulted from changes in the doses used to select these mice and/or the induction of specific ethanol metabolizing systems.
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影响因子：
6.7
作者：
B. Madsen;Lorena Rossi
通讯作者：
Lorena Rossi
高浓度酒精的代谢：肝微粒体乙醇氧化系统的作用和生化性质。
影响因子：
--
作者：
R. Teschke;S. Matsuzaki;K. Ohnishi;Y. Hasumura;C. Lieber
通讯作者：
C. Lieber
昼夜节律和遗传对 LS 和 SS 小鼠乙醇消除的影响。
DOI：
10.1111/j.1530-0277.1982.tb04989.x
发表时间：
1982
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Gilliam,DM;Collins,AC
通讯作者：
Collins,AC
乙醇的非线性药代动力学：不成比例的 AUC-剂量关系。
DOI：
10.1111/j.1530-0277.1980.tb04836.x
发表时间：
1980
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
P. Wilkinson;G. Reynolds;O. D. Holmes;S. Yang;L. O. Wilkin
通讯作者：
L. O. Wilkin
乙醇的时间药代动力学。
DOI：
--
发表时间：
1976
期刊：
影响因子：
--
作者：
Sturtevant Fm
通讯作者：
Sturtevant Fm